The Sp1 Transcription Factor Is Crucial for the Expression of 11β-Hydroxysteroid Dehydrogenase Type 2 in Human Placental Trophoblasts

Jianneng Li,Yuchun Ge,Zhihong Yang,Chunming Guo,T. Duan,Leslie Myatt,Haiyan Guan,Kaiping Yang,Kang Sun

The Sp1 Transcription Factor Is Crucial for the Expression of 11β-Hydroxysteroid Dehydrogenase Type 2 in Human Placental Trophoblasts

2011

Jianneng Li
Yuchun Ge
Zhihong Yang
Chunming Guo
T. Duan
Leslie Myatt
Haiyan Guan
Kaiping Yang
Kang Sun

The dramatic induction of 11β-HSD2 upon syncytialization of placental trophoblasts is due to enhanced Sp1 function rather than the demethylation of HSD11B2 promoter.

Keywords:

Syncytiotrophoblasts
Methylation
Trophoblast
Cytotrophoblast
Placenta
Endocrinology
Internal medicine
Sp1 transcription factor
Demethylation
Hydroxysteroid dehydrogenase
Medicine
Hydroxysteroids

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