Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.

Hailong You,Yao Jin,Jinsong Kang,Ying Mao,Jing Su,Liankun Sun,Li Wang,Hao Meng

Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.

2020

Hailong You
Yao Jin
Jinsong Kang
Ying Mao
Jing Su
Liankun Sun
Li Wang
Hao Meng

Serine protease Omi/HtrA2, a member of the HtrA family, is closely related to the maintenance of mitochondrial integrity and participates in apoptosis but its role in cerebral ischemia/reperfusion ...

Keywords:

Reactive oxygen species
mitochondrial fusion
Apoptosis
Reperfusion injury
Chemistry
Cell biology
XIAP
PMSF
Oxidative stress
HSP60

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