Separate identities of ligandin and the h-protein, a major protein to which carcinogenic hydrocarbons are covalently bound.

Abstract There is a protein moiety in the C3H mouse liver cytosol which gives a line of identity with rat liver ligandin one of three azo dye binding proteins of the liver using anti-rat ligandin. This mouse liver protein has been termed mouse ligandin and is not the h -protein, the major target protein in the mouse liver of methylcholanthrene and its metabolites. Mouse ligandin is identical to a minor methylcholanthrene binding protein species that was found previously to consist of basic proteins II and III. Both mouse ligandin and mouse h -protein contain glutathione S-transferase activity with different substrate specificitles.