Glucose oxidation by adipose tissue of the edible dormouse (Gus glis) during hibernation and arousal: Effect of insulin

Abstract 1. 1. The effect of insulin on U- 14 C-glucose oxidation by adipose tissue isolated from hibernating or arousing edible dormouse has been studied. 2. 2. CO 2 production derived from radioglucose was analysed point by point during in vitro rewarming (from 6 to 37°C). 3. 3. The rate of temperature increase was 2°/5 min in order to mimic the rate of rewarming during the spontaneous arousal of the dormouse. 4. 4. Insulin did not increase the glucose oxydation by the adipose tissue from hibernating dormouse whereas adipocytes from active animal present high insulin sensitivity. 5. 5. These results suggest that insulin resistance occurs during hibernation.