Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors.

1. Abstract 2. Introduction 3. Materials and Methods 3.1. Animals 3.2. Superovulation 3.3 Early pregnancy and pseudopregnancy 3.4. Artificial decidualization 3.5. Measurement of vascular permeability of rat implantation sites 3.6. Treatments with COX-2 inhibitors 3.7. Immunohistochemistry 3.8. Statistical Analysis 4. Results 4.1. Effects of COX-2 inhibitors on rat ovulation 4.2. Effects of nimesulide on rat embryo implantation 4.3. Effects of nimesulide on vascular permeability 4.4. Effects of nimesulide on the expression of implantation-related proteins 4.5. Effects of nimesulide on rat decidualization 4.6. Effects of COX-2 inhibitors on artificial decidualization 4.7. Effects of COX-2 inhibitors on rat gestational length and birth weight 5. Discussion 5.1. COX-2 action in rat ovulation 5.2. COX-2 action on rat implantation 5.3. COX-2 action on rat decidualization 5.4. The secondary effects of nimesulide treatment on rat reproduction 6. Acknowledgment 7. References