Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

Xiaoyang Lan,David J. Jörg,Florence M.G. Cavalli,Laura M. Richards,Long V. Nguyen,Robert Vanner,Paul Guilhamon,Lilian Lee,Michelle Kushida,Davide Pellacani,Nicole I. Park,Fiona J. Coutinho,Heather Whetstone,Hayden J. Selvadurai,Clare Che,Betty Luu,Annaick Carles,Michelle Moksa,Naghmeh Rastegar,Renee Head,Sonam Dolma,Panagiotis Prinos,Michael D. Cusimano,Sunit Das,Mark Bernstein,Cheryl H. Arrowsmith,Andrew J. Mungall,Richard A. Moore,Yussanne Ma,Marco Gallo,Mathieu Lupien,Trevor J. Pugh,Michael D. Taylor,Martin Hirst,Connie J. Eaves,Benjamin D. Simons,Peter B. Dirks

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

2017

Using unique barcodes for tumour cells, the authors explore the dynamics of human glioblastoma subpopulations, and suggest that clonal heterogeneity emerges through stochastic fate decisions of a neutral proliferative hierarchy.

Keywords:

CNS cancer
Neuroscience
Glioblastoma
Fate mapping
Stem cell
Hierarchy
Cancer stem cell
Invariant (mathematics)
Biology
Population
Cellular differentiation
Cancer research
Somatic evolution in cancer
Cell fate determination
Progenitor cell

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