A Wearable Wireless Electrochemical Instrument Used for In-vivo Neurotransmitter Detection

A wireless electrochemical recording device was designed for in-vivo neurotransmitters real-time detection. Low-power microcontroller MSP430 was chosen as main control unit in hardware system. Other modules were current detection module,waveform generator module and data transceiver module. This device had the merits of small size( 2. 3 cm × 1. 8 cm × 0. 6 cm) and low power consumption. Firmware program design was based on u C / OS operating system. Combined with the PC software,the device could achieve online display and analysis of the recording data. For neurotransmitter detecting needs, the device implemented fast-scan cyclic voltammetry( FSCV) and fixed-potential amperometry. By using fast-scan cyclic voltammetry method,a linear relationship( R = 0. 99) between the concentration of dopamine and response current was acquired in the range of 5. 0 × 10#7- 7. 0 × 10#5mol / L. In the in-vivo experiments,the electrically evoked dopamine was recorded in the caudate-putamen area of brain in rats. Experimental results showed that the system had high detection accuracy,which could realize qualitative and quantitative analysis of the brain neurotransmitter. This work would have a broad application prospect in the field of neuroscience research.