Derivatives of 3- (4-2-ylmethylidene amidopirrol-) -2-indolinone protein kinase inhibitors.

Compound of Formula ** ** wherein: R1 is selected from the group consisting of hydrogen, halo, C1-C10 alkyl, C1-C4 haloalkoxy, C3-C8 monocyclic cycloalkyl, [5, 6] - or [6, 6] -cycloalkyl fused bicyclic, adamantyl, a heteroalicyclic group 5-9 membered 1 or 2 heteroatoms selected from N, O or -S (O) n where n = 0-2, hydroxy, C1-C10 cycloalkoxy C3-C8 unsubstituted, -C (O) -R8, -NR9R10 and -C (O) NR12R13; R2 is selected from the group consisting of hydrogen, halo, C1-C10 alkyl, trihalomethyl, hydroxy, C1- C10 alkyl, C3-C8 cycloalkoxy unsubstituted, cyano, -NR9R10 alkyl, - NR 9 C (O) R10, -C (O) R8 , -S (O) 2NR9R10 and -SO2R14 (where R14 is a C1-C10 alkyl, C6-C12 aryl, C1-C4 alkyl substituted with C6-C12 aryl, a 5-12 membered heteroaryl containing 1-4 ring heteroatoms selected from the group of N, O or S, and C1-C4 alkyl substituted with a 5-12 membered heteroaryl containing 1-4 ring heteroatoms selected from N, O or S; R3, R4 and R5 are independently hydrogen or C1 C10.