Histopathological changes of prostate cancer after castration therapy and correlative factors

Objective To study the histopathological changes of prostate cancer after castration thera py among Chinese and correlative factors. Methods Needl e biopsy specimens and prostatectomy specimens were obtained from 17 cases of pr ostate cancer and examined by light microscopy and image analysis system. Results Glandular atrophy, cytoplasmic vacuolization, nuclear pyknosis, and relative increase of stroma could be seen after orchectomy. There was a close correlatio n between atrophy of neoplastic tissue in prostate gland and patients' age ( P 0. 05). The atrophy of neoplastic tissue in prostate gland was not correlated with the serum PSA, tumor staging and grading before castration therapy ( P 0.05). Conclusion Castration is effective for treatment of prostate cancer, especially a mong the elderly patients. It is important for pathologists to recognize the his topathological changes in the prostectomy specimens made untypical by castration .