Puma is required for p53-induced depletion of adult stem cells

Dongping Liu,Linda Ou,Gregory D. Clemenson,Connie Chao,Marshall Eli Lutske,Gerard P. Zambetti,Fred H. Gage,Yang Xu

Puma is required for p53-induced depletion of adult stem cells

2010

Dongping Liu
Linda Ou
Gregory D. Clemenson
Connie Chao
Marshall Eli Lutske
Gerard P. Zambetti
Fred H. Gage
Yang Xu

Tumour suppressor p53 is activated by phosphorylation. Phosphomimetic p53 expression in mice depletes stem cells by activating pro-apoptotic Puma. Puma depletion prevents premature stem cells depletion.

Keywords:

Cell biology
Progeria
Puma
Adult stem cell
Stem cell
Phosphorylation
Suppressor
Molecular biology
DNA damage
Apoptosis
Biology
Phenotype

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations