Highly-sensitive electrochemical determination of rutin using NMP-exfoliated graphene nanosheets-modified electrode

Graphene nanosheets (GS) were prepared through solvent exfoliation, and used to greatly enhance the oxidation activity of rutin. On the surface of GS, a sensitive oxidation wave at 0.26 V was observed for rutin, and the peak currents increased significantly. As a result, a highly sensitive electrochemical method was developed for the determination of rutin. The linear range was from 10 nM to 1.25 μM, and the detection limit was 3.2 nM. It was used in the analysis of traditional Chinese medicines, and the results consisted with the values of that obtained by high performance liquid chromatography.