16 – Hematopoietic Stem Cell Therapy

SECTION I: ISSUES RELEVANT TO THE PRE-TRANSPLANT PERIOD Clinical Indications Aplastic Anemia Acute Myelogenous Leukemia Acute Lymphoblastic Leukemia Chronic Myelogenous Leukemia Myelodysplasia Hodgkin Disease Lymphoma Multiple Myeloma Chronic Lymphocytic Leukemia Breast Cancer Ovarian Cancer Childhood Solid Tumors Germ Cell Tumors Hematopoietic Stem Cell Transplantation for Treatment of Congenital Immunodeficiencies Metabolic Diseases Hemoglobinopathies Gaucher Disease Hematopoietic Stem Cell Transplantation for Severe Autoimmune Diseases: Know Thyself In Utero Transplantation Evaluation of the Transplant Candidate Evaluation of Patients before Hematopoietic Stem Cell Transplantation Donor Selection and Evaluation Histocompatibility Choice of Donor: Immunogenetic and Functional Considerations Vascular Access Long-Term Venous Access During Hematopoietic Stem Cell Transplant Graft Procurement Bone Marrow Harvesting Peripheral Blood Progenitor Cell Mobilization and Collection Cord Blood Stem Cells Stem Cell Quantification Stem Cell Quantification: The ISHAGE Guidelines for CD34+ DeterminationApplications in Autologous and Allogeneic Blood and Marrow Transplantation Graft Engineering Mechanics Graft Processing, Storage and Infusion Purging of Contaminating and Tumor Cells T-Cell Depletion and Allograft Engineering Immunomodulation After Transplantation Ex Vivo Stem Cell Expansion Hematopoietic Stem Cells as Targets for Gene Therapy SECTION II: ISSUES RELEVANT TO THE IMMEDIATE TRANSPLANT PERIOD Treatment Regimens High Dose Chemotherapy Regimens for Use with Autologous or Allogeneic Hematopoietic Stem Cell Support Choice of Conditioning Regimens Infection Prophylaxis Viral Infections Bacteria Fungi and Other Organisms Graft-Versus-Host Disease Prophylaxis Graft-Versus-Host Disease Prophylaxis Use of Hematopoietic Growth Factors Use of Hematopoietic Growth Factors Coagulation Issues Coagulation Issues Nutritional Support Nutritional Support Section III: Complications The Immediate Post-Transplantation Period Infection Failure of Engraftment Therapy of Acute Graft-Versus-Host Disease Liver Disease in Hematopoietic Stem Cell Transplantation Recipients Mucositis and other Gastrointestinal Complications Respiratory Complications Neurological Complications Transfusion Support in Hematopoietic Stem Cell Transplantation Surgical Emergencies Later Onset Late Graft Failure Infection and Immunization Chronic Graft-Versus-Host Disease Endocrine and Metabolic Complications Relapse After Hematopoietic Stem Cell Transplantation: Mechanisms and Treatment Myelodysplasia and Second Malignancies Section IV: Post-Transplant Therapy Conventional Biologic Therapy Biologic Therapy After Stem Cell Transplantation Cytotoxic Therapy Post-transplant Cytotoxic Therapy Section V: Associated Issues Psychological Considerations Psychosocial Considerations: A Family Approach to Patient Care Specialized Nursing Specialized Nursing Coordination and Data Collection Coordination and Data Collection Biostatistics Biostatistics The Economics of Bone Marrow Transplantation Economics Section VI: Regulatory Issues Regulation of Hematopoietic Stem Cell Therapy