The Niche Regulation of Hematopoietic Stem Cells

Stem cells’ major capabilities, that is, pluripotency and self-renewal, are key to sustaining the lifelong functionality of organs. Stem cells reside in the special microenvironment called the niche. The niche and stem cells adhere to each other via adhesion molecules and exchange the molecular signals that maintain stem cell features. It has been suggested that tumor tissue also contains such type of cells.