Relationship of Na-K-ATPase inhibitors to blood-pressure regulation in continuous ambulatory peritoneal dialysis and hemodialysis.

Inhibitors of sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) have been implicated In the pathogenesis of hypertension. In the study presented here, an alfempt was made to determine whether differences in the plasma levels and the removal rates of high-molecular weight (HMW) and low-molecular weight (LMW) forms of Na-K-ATPase Inhibitors might relate to blood-pressure control in hemodlalysis (N = six ultrafiltered and N = six nonultrafiltered) and CAPD (N = six long-term and N = five short-term) patients. The latter group was studied before the initiation of continuous ambulatory peritoneal dialysis (CAPD) and 2 wk after starting the treatment. The mean blood pressure was significantly reduced after dialysis in the nonultrafiltered hemodialysis group and in both CAPD groups. Plasma levels of both HMW and 1MW inhibitors were found to be