Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily.

Introduction: Guanine nucleotide binding proteins (G-proteins) represent the targets for >50% of all therapeutics. There is substantial interindividual variation in response to agonists and antagonists directed to these receptors, which may, in part, be due to genetic polymorphisms. As a class, the sequence variability of G-protein-coupled eceptor (GPCR) genes has not been characterized.