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Stephen B. Liggett

University of Cincinnati Academic Health Center
University of Maryland, Baltimore
University of South Florida

319

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23951

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β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy.

2022
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Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment.

2021 Journal of Physical Chemistry Letters
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Identification and characterization of an atypical Gαs-biased β2AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis.

2021 Proceedings of the National Academy of Sciences of the United States of America
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The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14.

2021 Journal of Biological Chemistry
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Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5

2020
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β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates

2020 Proceedings of the National Academy of Sciences of the United States of America
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β‐arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates: Molecular and cell biology: Tau‐related mechanisms

2020 Alzheimers & Dementia
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The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR

2020 Proceedings of the National Academy of Sciences of the United States of America
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Deep Resequencing of the Beta-2 Adrenergic Receptor Gene (ADRB2) in COPD and Asthma Cohorts Identifies Functional Rare Variants

2020
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Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal–regulated Kinase 1/2

2019 American Journal of Respiratory Cell and Molecular Biology
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