Expression of Aurora A protein in neuroblastic tumors and its relationship with clinical feature

Objective To investigate the expression of Aurora A protein in neuroblastic tumors(NT) and its relationship with clinical features. Methods From April 2008 to June 2015, total of 22 NT patients were collected as study group(n=22) from the Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology.Meanwhile 10 none-tumoral patients from the same hospital were included in the study as control group (n=10). The expressions of Aurora A protein were detected both in neuroblastic tissues samples of NT patients from study group and in bone marrow samples of non-tumoral patients from control group by technology of immunohistochemistry. The relationship between NT clinical features and the expressions of Aurora A protein were observed. Results ①There were 68.2% of patients were showed with positive expression of Aurora A protein in study group, meanwhile no one showed that in control group, and the differences had statistical significance(P 0.05). Conclusions Aurora A protein is highly expressed in NT, and its corresponding Aurora A kinase inhibitors may be a new target for the treatment of NT. Key words: Neuroblastoma; Prognosis; Aurora A