The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

Alberto Baroja Mazo,Fátima Martín Sánchez,Ana I. Gómez,Carlos Martínez,Joaquín Amores-Iniesta,Vincent Compan,Maria Barberà-Cremades,Jordi Yagüe,Estíbaliz Ruíz-Ortiz,Jordi Anton,Segundo Buján,Isabelle Couillin,David Brough,Juan I. Aróstegui,Pablo Pelegrín

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

2014

Alberto Baroja Mazo
Fátima Martín Sánchez
Ana I. Gómez
Carlos Martínez
Joaquín Amores-Iniesta
Vincent Compan
Maria Barberà-Cremades
Jordi Yagüe
Estíbaliz Ruíz-Ortiz
Jordi Anton
Segundo Buján
Isabelle Couillin
David Brough
Juan I. Aróstegui
Pablo Pelegrín

The NLRP3 inflammasome is involved in IL-1 production and pyroptosis. Pelegrin et al. demonstrate that it is also released extracellularly as a functional proinflammatory particle.

Keywords:

AIM2
Cell biology
Immunology
Pyroptosis
Proinflammatory cytokine
Biology
NALP3
Inflammasome
Autoinflammatory Syndrome
inflammatory response
danger signal

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