NALP3

3QF2, 2NAQ114548216799ENSG00000162711ENSMUSG00000032691Q96P20Q8R4B8NM_183395NM_145827NM_001359638NP_899632NP_665826NP_001346567NACHT, LRR and PYD domains-containing protein 3 (NALP3), also known as cryopyrin, is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1. NACHT, LRR and PYD domains-containing protein 3 (NALP3), also known as cryopyrin, is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1. NALP3 is expressed predominantly in macrophages and as a component of the inflammasome,:436 detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NALP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.