SPECTROPHOTOMETRIC DETERMINATION OF NAPROXEN AND ESOMEPRAZOLE IN A LABORATORY MIXTURE BY SIMULTANEOUS EQUATION, ABSORPTION CORRECTION, ABSORPTION RATIO AND AREA UNDER CURVE METHODS

An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of naproxen (NP) and esomeprazole (EOZ) in a laboratory mixture of these two components. The method involves area under curve (AUC) method in the range 227-237nm and 296.5-306.5nm respectively, formation of simultaneous equation at 232nm and 301.5nm respectively, absorption correction method at 232nm λmax of naproxen, 239.2nm isoabsorptive point of NP & EOZ & 301.5nm for absorption ratio method by using methanol as a solvent. The linearity for both naproxen and esomeprazole was in the range of 1- 5 µg/ml and 4-12µg/ml respectively. The % recovery was found to be 98.23% and 98.87% for naproxen and esomeprazole respectively indicating proposed method is accurate and precise for simultaneous estimation of naproxen and esomeprazole in bulk formulations.