A simple synthesis of a highly water soluble symmetrical β-cyclodextrin derivative

Abstract 1,3-dipolar cycloaddition between peracetyl-heptakis-6-azido-6-deoxy-β-cyclodextrin and the dimethylester of 2-butyne dicarboxylic acid is a highly efficient route for the introduction of seven 1,2,3-triazole heterocycles and fourteen carboxyl groups on the small rim of the macrocycle.