Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

Background It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.