Proliferation of Skeletal Muscle Satellite Cells after Castration and Administration of Testosterone Propionate
1988
AbstractThirty-six neonatal pigs were randomly assigned to the following treatment groups: sham implanted gonadally intact males (B), sham-implanted castrated males (C), or castrated males implanted with testosterone propionate (C + TP). Four pigs from each group were sacrificed at 7, 14, or 21 days of age after a 6-hr continuous infusion of [3H]thymidine. Myo-fibers isolated from the triceps brachii were prepared for satellite cell enumeration by light microscope autoradiography. A developmental decline in labeled myofiber nuclei occurred in all groups, however, the greatest decline occurred in C (P < 0.01). A treatment-by-age interaction was observed for percentage of labeled nuclei. Castration reduced total and labeled nuclei per millimeter myofiber (P < 0.05), and C + TP had a higher percentage of labeled nuclei than C (2.8 vs 2.2%; P < 0.05). Since triceps brachii muscles from 21 day B and C + TP were 120% (P < 0.05) of C, the results indicate that postnatal growth of skeletal muscle is dependent on ...
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