[18F]FDDNP performed better than [18F] Florbetapir to distinguish transthyretin cardiac amyloidosis (TTR-CA) patients from healthy controls: an ex vivo study

Background TTR-CA is characterized by extracellular depositions of amyloid b (Ab) which can lead to arrhythmias, heart failure and even sudden death. While early diagnosis of TTR-CA has important therapeutic and prognostic impact, there is no sensitive and quantitative tool to document the location and extent of cardiac Ab in these patients. So we aimed to test and compare the usefulness for TTR-CA early diagnosis of both [18F]florbetapir and [18F]FDDNP, 2 PET tracers validated for brain detection of Ab.