Polymerization site in the .beta. chain of fibrin: mapping of the B.beta.1-55 sequence

The formation of a fibrin clot occurs through binding of putative complementary sites, called fibrin polymerization sites, located in the NH 2 - and COOH-terminal domains of fibrin monomer molecules. In this study, we have investigated the structure of the NH 2 -terminal fibrin polymerization site by using fibrinogen-derived peptides and fragments.