Expression of Lysyl Oxidase Predictive of Distant Metastasis of Laryngeal Cancer

ObjectiveTo investigate the prognostic significance of lysyl oxidase (LOX) expression in laryngeal cancer.Study DesignRetrospective chart review and histologic analysis.SettingTertiary referral academic center.Subjects and MethodsPatients (N = 100) underwent surgical treatment for laryngeal cancer and had tissue specimens available. Immunohistochemical staining for LOX was performed on laryngeal cancer tissue microarrays, and the proportion and intensity of staining were evaluated. Patients with LOX scores ≤6 were classified into the low LOX group, while those with scores >6 were classified into the high LOX group. We analyzed the correlation between LOX expression and clinical factors as well as prognosis.ResultsLOX was predominantly expressed in the cytoplasm and nuclei of tumor cells. Kaplan-Meier analysis revealed that the high LOX group had worse overall survival and recurrence-free survival rates than the low LOX group (P < .05). LOX expression exhibited marginally significant correlation with lymph...