Application prospect of umbilical cord mesenchymal stem cells mediated by Wnt/β- catenin signaling for repair of diabetic wounds

The pathogenesis of diabetes wounds is complicate, and there lacks effective treatment strategies. Mesenchymal stem cells can promote wound healing. Compared with bone marrow mesenchymal stem cells, umbilical cord mesenchymal stem cells have obvious advantages in biological property. Wnt is potent regulatory molecules for stem cell turnover and skin regeneration, while the function of Wnt signaling pathway in diabetic wound is low. Umbilical cord mesenchymal stem cells mediated by Wnt/β- catenin signaling have some application potential in the repair of diabetic wounds. In this paper, the authors summarize the current situation and existing problems in this field. Key words: Mesenchymal stem cells; Wnt signaling pathway; Diabetes mellitus; Wound healing