Telomeres and telomerase in cancer

Preface Contributors Part I. Basic background 1 Telomeres and Telomerase in Human Keiko Hiyama, Eiso Hiyama, and Jerry W. Shay 2 Telomere Binding Proteins in Human Nadya Dimitrova 3 Regulation of Telomerase through Transcriptional and Post-Translational Mechanisms Amy N. Depcrynski, Patrick C. Sachs, Lynne W. Elmore, and Shawn E. Holt 4 Telomere Dysfunction and the DNA Damage Response Malissa C. Diehl, Lynne W. Elmore, Shawn E. Holt 5 Alternative Lengthening of Telomeres (ALT) in Human Cells Hilda A. Pickett and Roger R. Reddel 6 Mouse model: Telomeres and Telomerase in Stem Cell and Cancer Xin Huang, Zhenyu Ju Part II Telomeres and telomerase in human cancers 7 Role of Telomeres and Telomerase in Cancer Keiko Hiyama, Eiso Hiyama, Keiji Tanimoto, Masahiko Nishiyama 8 Diagnostic Value 1: Solid Tumors Eiso Hiyama and Keiko Hiyama 9 Diagnostic Value 2: Hematopoietic Malignancies Junko H. Ohyashiki and Kazuma Ohyashiki 10 Therapeutic Targets and Drugs 1: Telomerase and Telomerase Inhibitors Brittney-Shea Herbert and Erin M. Goldblatt 11 Therapeutic Targets and Drugs 2: G-quadruplex and G-quadruplex Inhibitors Chandanamali Punchihewa and Danzhou Yang 12 Therapeutic Targets and Drugs 3: Tankyrase 1, Telomere Binding Proteins, and Inhibitors Hiroyuki Seimiya and Takashi Tsuruo 13 Therapeutic Targets and Drugs 4: Telomerase-specific Gene and Vector-based Therapies for Human Cancer Toshiyoshi Fujiwara, Yasuo Urata, and Noriaki Tanaka Part III Experimental protocols 14 Protocol 1: Telomerase Activity and Telomerase Expression Eiso Hiyama 15 Protocol 2: Importance and Methods of Telomere G-tail Length Quantification Akira Shimamoto, Eriko Aoki, Angie M Sera, Hidetoshi Tahara 16 Protocol 3: Detection of Alternative Lengthening of Telomeres (ALT) Wei-Qin Jiang, Jeremy D. Henson, Axel A. Neumann, and Roger R. Reddel Index