Potential therapeutic properties of Sorbus commixta twig ethanol extract on vitiligo in skin cells
2021
Sorbus commixta is a tree of the Rosaceae family growing in Asia that has
long been used to treat asthma and neuralgia. In a previous report, the
chemical isolated from the bark of S. commixta was shown to suppress the
production of nitric oxide (NO) and preinflammation by down regulating the
NF-кB pathway in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Vitiligo
is an acquired immune disease, usually characterized by white spots on the
skin; however, its exact cause has not been identified. This study assessed
the effects of an ethanol extract of S. commixta twigs (STE) on melanocyte
activation, as well as its antiinflammatory and antioxidant properties. STE
significantly increased the proliferation and melanin content of B16
melanocytes. Because of the importance of tumor necrosis factor (TNF)-α in
inflammatory diseases, including the stimulation of vitiligo, the
antiinflammatory effects of STE were tested in TNF-α-stimulated dermal
fibroblasts and keratinocytes. STE reduced the levels of expression of IL-6,
IL-8 and TNF- α mRNA and proteins. To assess the underlying molecular
mechanism, the effects of STE on the mitogen-activated protein kinase (MAPK)
signaling process were analyzed in dermal fibroblasts. Results show that STE
inactivated extracellular signal-regulated kinase (ERK). In addition, STE
exhibited antioxidative properties in assays of DPPH radical scavenging
activity. Taken together, these findings suggest that STE has potential
therapeutic activity in vitiligo.
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