2,7-substituted thiophene as protein kinase inhibitors and [3,2-d] pyrimidine compounds

It discloses a protein kinase inhibitory activity of 2,7-substituted thiophene and [3,2-d] pyrimidine compound, a pharmaceutically acceptable salt thereof, and comprising the compound as an active ingredient for the prevention and treatment of diseases caused by abnormal cell growth of the pharmaceutical composition. Since the novel 2,7-substituted thieno [3,2-d] pyrimidine compound of growth factor signal transduction involved in a variety of protein kinases exhibit excellent inhibitory activity, so as for the prevention or treatment of abnormal Pharmacy diseases caused by cell growth is useful.