EVALUATION OF TRYPAN-BLUE TOXICITY IN MACULAR HOLE SURGERY WITH ELECTRORETINOGRAPHY EVALUACIÓN MEDIANTE ELECTRORRETINOGRAFÍA DE LA TOXICIDAD DEL AZUL TRIPÁN EN LA CIRUGÍA DEL AGUJERO MACULAR

Purpose: Concern has been raised about the retinal toxicity of vital dyes. We designed a prospective study to determine the possible toxicity of trypanblue (TB) in macular hole surgery with TB-assisted internal limiting membrane (ILM) peeling through the performance of electroretinograms (ERGs). Methods: Patients diagnosed with a macular hole underwent ophthalmological evaluation prior to surgery and at 6 months follow-up. All patients underwent vitrectomy and ILM-staining under air. All phakic patients underwent phacoemulsification and IOL implantation simultaneously. There were two study groups: In group 1, ILM-staining was performed with 0.06% TB, while in group 2 the procedure was performed with 0.15% TB. Preoperative ERG recordings were measured in the week prior to surgery. Postoperative ERGs were measured 3 to 6 months after surgery. The ERG data between eyes with macular hole and fellow eyes were compared in the pre- and post-operative stages. Visual acuity (VA) changes in both groups were evaluated. Results: Nine patients were recruited in each group. VA improved significantly in both groups,