Potentials of sandwich-like chitosan/polycaprolactone/gelatin scaffolds for guided tissue regeneration membrane

Abstract Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding. Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property. To overcome these shortcomings, we generated unique multifunctional scaffolds. A chitosan/polycaprolactone/gelatin sandwich-like construction was fabricated by electrospinning and lyophilization. These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (