Metronidazole Esters: A New Class of Antiglycation Agents
2012
A series of metronidazole ester derivatives 1-34 has been synthesized with the aim of developing new leads
with antiglycation activity. The in vitro evaluation of antiglycation potential of 1-34 showed that the ester derivatives 28,
16, and 3 have IC50 values 218.97 ± 2.5, 245.3 ± 5.1, and 278.6 ± 0.8 μM, respectively, comparable to the standard agent,
rutin (IC50 = 294.5 ± 1.50 μM). The study identifies a new class of potent antiglycation agents. A structure-activity
relationship has also been evaluated. All the compounds were characterized by using spectroscopic techniques, including
1H NMR, IR, and EI-MS.
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