Optimization of a plasmonic fluorescence biosensor platform to detect serum antibodies with high sensitivity and consistency (Conference Presentation)

Detection of antibodies in the blood is an important clinical technique for diagnosing active infections and previous exposures. The grating-coupled fluorescent plasmonics (GC-FP) biosensing platform has been used to detect Lyme disease serum antibodies in patients and has been shown to be more sensitive than the current standard tests. In this study, we sought to design an affordable GC-FP detection system without sacrificing the sensitivity of data output. We further optimized our analysis strategies to achieve highly sensitive and consistent diagnostic results. This work ultimately aims to fill an unmet need for better detection of human Lyme disease.