Abstract 12102: TNNI3-K183del Mutation in Dilated Cardiomyopathy Patient-Specific iPSC-Derived Cardiomyocytes Affects Structural Proteins and Ion Channels, Leading to Impair the Function of Cardiomyocytes

Nagako Sougawa,Takuji Kawamura,Ryohei Matsuura,Junjun Li,Li Liu,Akima Harada,Maki Takeda,Noriko Oda-Mochizuki,Yoshiki Sawa,Shigeru Miyagawa

Abstract 12102: TNNI3-K183del Mutation in Dilated Cardiomyopathy Patient-Specific iPSC-Derived Cardiomyocytes Affects Structural Proteins and Ion Channels, Leading to Impair the Function of Cardiomyocytes

2021

Nagako Sougawa
Takuji Kawamura
Ryohei Matsuura
Junjun Li
Li Liu
Akima Harada
Maki Takeda
Noriko Oda-Mochizuki
Yoshiki Sawa
Shigeru Miyagawa

Background: One of the causes for Dilated cardiomyopathy (DCM) are thought to be genetic defect. One mutation, Lys183 del mutation of the TNNI3, is suggested to be associated with left ventricular ...

Keywords:

Cancer research
TNNI3
Cardiomyopathy
Ion channel
Function (biology)
Mutation (genetic algorithm)
patient specific
Stem cell
Dilated cardiomyopathy
Medicine

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