Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5–induced eosinophil development

Paired immunoglobulin-like receptors (PIRs) recognize β2-microglobulin. Munitz and colleagues show that PIR-A and PIR-B have opposing roles in eosinophil development in response to interleukin 5 in the bone marrow.