Prognostic impact of peripheral blood counts in patients with non-metastatic clear cell renal cell carcinoma.

e15590 Background: Peripheral blood counts (PBC) such as anemia and elevated platelets are associated with a worse prognosis in patients (pts) with metastatic clear cell renal cell carcinoma (ccRCC). The association of PBC in patients with non-metastatic ccRCC remains unclear. We performed a retrospective analysis to assess the impact of PBC on RCC-specific survival (RCC-SS) and relapse free survival (RFS). Methods: We abstracted available PBC values within 30 days of nephrectomy for all pts enrolled in the Mayo Clinic Renal Registry from 1990-2009 treated for localized (M0) ccRCC. PBC values included hemoglobin (HGB), white blood cell (WBC), absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute eosinophil count (AEC), absolute monocyte count (AMC), and platelets (PLT). To correct for skewed data, we transformed PBC values via the square root transform. We analyzed the correlation of PBC values with both RFS and RCC-SS using age-adjusted Cox regression models. We then assessed the ind...