The association study between polymorphisms of FK506-binding proteins 5 gene and major depressive disorder

Objective To explore the association between FK506-binding proteins 5(FKBP5) gene (rs1360780) polymorphisms and major depressive disorder (MDD) in Han Chinese. Methods Genotypes and allele frequencies of rs1360780 of FKBP5 gene were examined in 250 patients and 300 healthy controls by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). T-test, Hardy-Weinberg equilibrium and chi-square test were used to conduct statistical analysis. Results (1)The FKBP5 genotypes and alleles frequency distribution between MDD patients ( CC, CT, TT genotypes: 59.6%, 36.0%, 4.4%.C, T alleles: 78.2%, 21.8% ) and controls ( CC, CT, TT genotypes: 59.0%, 36.3%, 4.7%.C, T alleles: 77.2%, 22.8% ) had no significant difference (P=0.983.P=0.682). (2) However, the frequency of FKBP5 genotypes and alleles distribution between MDD patients ( CC, CT, TT genotypes: 59.6%, 36.0%, 4.4%.C, T alleles: 78.2%, 21.8% ) and controls ( CC, CT, TT genotypes: 59.0%, 36.3%, 4.7%.C, T alleles: 77.2%, 22.8% ) had statistically difference in male subjects (P=0.046.P=0.012) and subjects with T allele have a higher risk compared to those with C allele to develop MDD (OR=2.185, 95% CI=1.181-4.042). (3) The score of HAMD, retard factor, sleep factor, Maier factor, anxiety/somatization factor and core factor in MDD patients with different genotypes had no significant difference (P>0.05). Conclusion The results suggest that FKBP5 rs1360780 polymorphisms are associated with the onset of MDD in male Han Chinese.T allele is a risk factor of MDD. Key words: Major depressive disorder; FK506-binding proteins 5; Gene polymorphism