FKBP5

1KT0, 3O5D, 3O5E, 3O5F, 3O5G, 3O5I, 3O5J, 3O5K, 3O5L, 3O5M, 3O5O, 3O5P, 3O5Q, 3O5R, 4DRH, 4DRI, 4DRK, 4DRM, 4DRN, 4DRO, 4DRP, 4DRQ, 4JFI, 4JFJ, 4JFK, 4JFL, 4JFM, 4R0X, 4TW6, 4TW7, 4TX0, 4W9O, 4W9P, 4W9Q, 5DIT, 5DIU, 5BXJ, 5DIV228914229ENSG00000096060ENSMUSG00000024222Q13451Q64378NM_004117NM_001145775NM_001145776NM_001145777NM_010220NP_001139247NP_001139248NP_001139249NP_004108NP_034350FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene.1kt0: Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes1kt1: Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes (i.e. progesterone-, glucocorticoid-, mineralocorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein. The FKBP5 gene has been found to have multiple polyadenylation sites and is statistically associated with a higher rate of depressive disorders. FKBP5 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.