Influence of Different Stem Cell Mobilization Strategies on Graft Composition and Outcome of Autologous or Allogeneic Transplantation

Autologous and allogeneic hematopoietic stem cell (HSC) transplantation are considered the standard of care for many malignancies including lymphoma, myeloma, and some leukemias. In many cases, mobilized peripheral blood has become the preferred source for HSCs. The efficacy of different mobilization regimens and transplant outcomes based on cell doses has been well studied. However, the characteristics of the stem cell graft may be of equal importance with respect to patient outcomes following autologous or allogeneic transplant. This review summarizes available preclinical and clinical data for bone marrow and mobilized peripheral blood HSC graft characteristics, defined as the cell types found in the graft as well as their gene expression profiles. This manuscript also explores how graft characteristics can impact bone marrow homing, engraftment, immune reconstitution, and other posttransplant outcomes in both the allogeneic and autologous settings.