✓ A randomized clinical study of irradiation and irradiation combined with ACNU in the treatment of malignant gliomas was performed in order to determine if there was an enhancing therapeutic effect of ACNU given in addition to radiotherapy. An effect was defined as a reduction in tumor size, changes in neurological signs and performance status within 1 month after the completion of radiotherapy, or statistically improved survival times. Seventy-seven patients from 14 neurosurgical clinics were included in this validated study group. Radiotherapy with a total dose of 5000 to 6000 rads, given in 25 to 30 subdoses, was applied to the whole brain and to a generous field surrounding the tumor. Patients who were assigned to receive chemotherapy were given ACNU intravenously once or twice during radiotherapy at a dose of 100 mg/sq m of body surface area. The response rate (more than 50% reduction of the tumor size) was 13.5% in the group treated by radiotherapy alone and 47.5% in the group with radiotherapy and ACNU. The hematological toxicity was more severe in the group treated with radiotherapy and ACNU. Other toxicity was mild and acceptable. The survival rates of patients with astrocytoma grade III and glioblastoma multiforme at 36 months after the surgery were 48.9% and 0% for radiotherapy alone and 59.0% and 16.3% for radiotherapy plus ACNU, respectively. The differences between the survival curves were not significant at the p = 0.05 level. This study has demonstrated that, although the use of ACNU during radiotherapy suppressed malignant gliomas more than radiotherapy alone, the survival time was not extended significantly. It is necessary to continue to search for an effective chemotherapeutic regimen to prolong survival of patients with malignant gliomas.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared multiphoton dissociation of heptafluoropropaneShuji. Kato, Yoshihiro. Makide, Kazuo. Takeuchi, and Takeshi. TominagaCite this: J. Phys. Chem. 1987, 91, 16, 4278–4284Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/j100300a016https://doi.org/10.1021/j100300a016research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A method is presented for the determination of the dissociation yield of UF6 in infrared laser isotope separation of uranium. The fluorescence intensity from vibrationally excited HF molecules in the dissociation with 16 μm infrared radiation is related to that in the dissociation with 266 nm ultraviolet radiation for which the absorption cross section and the quantum yield are known. One can calibrate the dissociation yield of UF6 from the fluorescence intensity in 16 μm irradiation, using the experimental result that the fluorescence signal linearly increases with the pulse energy of the 266 nm beam, and the relation derived theoretically between its energy and the number of dissociated molecules. The authors discuss how the fast thermalization of F atoms in both irradiation cases guarantees such a calibration method in spite of the difference in the translational energy of dissociation fragment F atoms.
A new biflavonoid, daphnodorin D (5) was isolated from the root of Daphne odora THUNB. Daphnodorin D was confirmed to be a mixture of atropisomers at C-8, C-3"linkage of 5, 7, 4'-trihydroxyflavan〓 5", 7", 4'''-trihydroxyflavone by chemical and spectroscopic means.
Abstract Abstract The radical reaction mechanisms in the presence of F-atom scavenger gases were investigated in the p-H2 Raman laser-induced infrared multiphoton dissociation (IRMPD) of gaseous 236UF6/238UF6 cooled to —35°C in a static gas cell. When CH4 was added as a scavenger of F-atoms produced via IRMPD of UFC, the dissociation rate of UF6 became several tens of times larger than when no scavenger gas was added. Gas-chromatographic analysis revealed that as low as 7% of the nascent CH3 radicals were involved in the radical reaction with UF6. On the other hand, H2 and C2H6 were found to increase both the dissociation rate of UF6 and the contribution of this non-selective reaction. These results agreed with those obtained in the UV photolysis of UF6 with scavengers. KEYWORDS: radical reaction mechanismreaction kineticsscavenger gas effectscavenginginfrared multiphoton dissociationuranium hexaftuoridelaser isotope separationp-H2 Raman laser
