Camila Manrique

University of Missouri

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James R. Sowers

University of Missouri

Guido Lastra

University of Missouri

Javad Habibi

University of Missouri

Adam Whaley‐Connell

University of Missouri

Annayya R. Aroor

University of Missouri

Guanghong Jia

University of Missouri

Melvin R. Hayden

University of Missouri

Vincent G. DeMarco

University of Missouri

Luis A. Martinez‐Lemus

University of Missouri

Ravi Nistala

University of Missouri

Cooperative Institutions

University of Missouri

119

Harry S. Truman Memorial Veterans' Hospital

University of Missouri Hospital

Hypertension Institute

Harvard University

Diabetes Australia

Wake Forest University

Cardiovascular Research Center

Tufts Medical Center

Shanghai Jiao Tong University

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The VASP Road to NAFLD: A Macrophage Detour

Diabetes (2015)

Guido Lastra Camila Manrique Guanghong Jia James R. Sowers

Nonalcoholic fatty liver disease (NAFLD), a common clinical disorder, is increasing largely due to increasing consumption of diets high in fructose and fat (1–3). Indeed, NAFLD has been reported to be present in up to 30% of the U.S. population (3), closely mirroring the prevalence of obesity. Its presence carries an increased risk for type 2 diabetes, end-stage liver disease, and cardiovascular disease (2). Obesity and type 2 diabetes are characterized by chronic low-grade inflammation in which maladaptive immune responses contribute to the development of resistance to the metabolic actions of insulin, thus generating a proinflammatory milieu that leads to steatosis and fibrosis of the liver (4). A critical event in the pathophysiology of tissue inflammation is the shift in the polarization status of macrophages from an anti-inflammatory (M2) to a proinflammatory (M1) phenotype of macrophages (5,6). M1 polarization of hepatic Kupffer cells (KCs) plays an important role in the genesis of hepatic steatosis and insulin resistance in response to chronic overnutrition (6). M1 polarization results in increased expression of proinflammatory mediators, such as CD11c, tumor necrosis factor α, interleukin (IL)-6, and inducible nitric oxide synthase (7). Conversely, the anti-inflammatory M2 phenotype secretes preferentially CD206, arginase1, and IL-10 (8). The role of macrophage M1/M2 polarization status in conditions of insulin resistance has been explored using myeloid-specific knockout …

Proinflammatory cytokine

Steatosis

Macrophage polarization

10.2337/db15-0551

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Contents Vol. 3-4, 2014

Cardiorenal Medicine (2014)

Fritha Morrison Huabing Zhang Stephen Skentzos Maria Shubina Rhonda Bentley–Lewis

10.1159/000370200

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Diabetes, Dislipidemia y Protección del Corazón

The Journal of Clinical Endocrinology & Metabolism (2009)

Camila Manrique James L. Rosenzweig Guillermo E. Umpiérrez

10.1210/jcem.94.1.9996

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A BRIEF COMMUNICATION

Experimental Biology and Medicine (2017)

Melvin R. Hayden Poorna R. Karuparthi Camila Manrique Guido Lastra Javad Habibi

In 2004, the human islet amyloid polypeptide (HIP) rat model was created by transfecting the Sprague-Dawley rat with the human islet amyloid polypeptide (hIAPP)-amylin gene. The objective of this study is to utilize the transmission electron microscope to study the longitudinal cellular and extracellular morphological changes within the islets of this model at 4, 8, and 14 months of age. It has been previously demonstrated that the 2-, 5-, and 10-month HIP models have no diabetes, impaired fasting glucose, and diabetes, respectively. The 4-month HIP model (FBS 123 mg/dl) demonstrated an abundance of β-cells and insulin secretory granules with significant pericapillary and inter-β-cell islet amyloid deposition. The 8-month model (FBS 187 mg/dl) demonstrated extensive islet amyloid deposition and marked changes of β-cell apoptosis. The 14-month-old model (FBS 244 mg/dl) demonstrated islet and β-cell atrophy with even greater amounts of extracellular islet amyloid compared to the 4-month-old and 8-month-old ...

Amylin

Amyloid (mycology)

10.3181/00379727-232-2320772

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Nebivolol in Obese and Non‐Obese Hypertensive Patients

Journal of Clinical Hypertension (2009)

Camila Manrique Adam Whaley‐Connell James R. Sowers

Use of beta-blockers in hypertensive obese patients remains controversial because of concerns about potential influences on weight, lipids, and glucose metabolism. The authors examined a pooled analysis of 3 multicenter randomized placebo-controlled trials. Patients were randomized to placebo or an increasing dose of nebivolol for 12 weeks. Primary outcome was the mean baseline to end point change in trough mean sitting diastolic blood pressure (SiDBP). Secondary outcomes were baseline to end point changes in trough sitting systolic blood pressure (SiSBP); trough standing and peak supine diastolic blood pressure and systolic blood pressure. Nebivolol reduced SiDBP significantly compared with placebo at all doses > or =2.5 mg in obese and non-obese patients. Reductions in SiSBP with nebivolol were higher than controls at all studied doses > or =5 mg in non-obese and > or =2.5 mg in obese patients. These findings and nebivolol's neutral effects on lipid and carbohydrate metabolism suggest that it is one option for blood pressure control in the moderately obese population.

Nebivolol

10.1111/j.1751-7176.2009.00119.x

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LOS GRUPOS DE FORMACIÓN DE LIDERAZGO Y EL DESARROLLO DE COMPETENCIAS DE LOS JÓVENES UNIVERSITARIOS

Refcale Revista Electrónica Formación y Calidad Educativa (2024)

D. Rodríguez Camila Manrique Andrea Katherine Miranda Anchundia

El objetivo fue investigar desde el contexto universitario la influencia de los grupos de liderazgo en el desarrollo de competencias de los jóvenes universitarios, ya que se evidencia debilidades en base a las investigaciones confirmadas en el antecedente como el bajo nivel de liderazgo que se presenta en los estudiantes en comparación de otras habilidades blandas; así como que las universidades no profundizan esta temática. En este estudio se aplicó el nivel teórico mediante un enfoque cuantitativo y cualitativo, aplicándose el método analítico-sintético, así mismo es de nivel empírico, de carácter descriptivo, de campo y relacional, a través de encuestas donde se estructuraron indicadores sobre participación en capacitación; en proyectos de liderazgo y habilidades pedagógicas de los mentores. Se realizó un muestreo por conveniencia no probabilística a 109 estudiantes de octavo y noveno semestre de la carrera Administración de Empresas de la Universidad Laica Eloy Alfaro de Manabí. Como resultados se evidenció un número significativo de estudiantes que no ha sido participes en actividades que fomenten el desarrollo de esta habilidad, pero existe un alto nivel de estudiantes que sienten interés por fortalecer el liderazgo, además se detectó que jóvenes les gustaría que la universidad implementara capacitaciones internacionales para el desarrollo de competencias y liderazgo, al mismo tiempo se identificó que las habilidades pedagógicas como la motivación y el apoyo de los mentores juegan un papel importante en la formación del liderazgo en los estudiantes

10.56124/refcale.v12i1.005

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Beta Cell Dysfunction, Oxidative Stress and S6K1 Activation in Pancreas in the Zucker Obese Rat Model

Guido Lastra Charles B Krueger Camila Manrique James R. Sowers

BETA (programming language)

10.1210/endo-meetings.2011.part3.p5.p2-480

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Insights into the emerging cardiometabolic prevention and management of diabetes mellitus

Expert Opinion on Pharmacotherapy (2005)

Guido Lastra‐González Camila Manrique Gurushankar Govindarajan Adam Whaley‐Connell James R. Sowers

Cardiovascular disease (CVD) and Type 2 diabetes mellitus (DM2), once conceived as different entities, share common origins and pathways. Increased activity of the renin-angiotensin-aldosterone-system, insulin resistance, chronic low-grade inflammation and oxidative stress collectively contribute to endothelial dysfunction and atherosclerosis, which manifest clinically as CVD. Nowadays, it is possible to identify and intervene in high-risk populations even before the clinical diagnosis of DM2. The control of dietary patterns and increased physical activity is completely feasible, as well as the management of hypertension and dyslipidaemia. Pharmacological interventions targeted at blocking renin-angiotensin-aldosterone-system and sensitising to insulin have a role in the prevention of DM2 and CVD, and are avidly explored worldwide. In the near future, ongoing trials should provide data that will allow us to better treat patients with the cardiometabolic syndrome and diabetes in order to reduce CVD morbidity and mortality.

Endothelial Dysfunction

10.1517/14656566.6.13.2209

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Síndrome cardiometabólico: Inflamación, tejido adiposo, resistencia a la insulina y aterogénesis se expande el rompecabezas

Acta Medica Colombiana (2005)

Guido Lastra G Camila Manrique Guido Lastra L

Over the last few decades, from being a purely esthetic problem without any pathological implications, obesity has become a true epidemic affecting more than a third of the Western population, involving an increasing number of people among the younger generations. Obesity is characterized by a myriad of metabolic derangements, in which adipose tissue plays a key role and has shown to be one of the most complex and fascinating endocrine organs discovered recently. Adipose tissue, whose essential role is to store the energy required to support metabolism and contribute to immunologic and reproductive functions, is compromised by genetic and environmental influences, which turn it into a dysfunctional tissue. Visceral adipose tissue in obesity is characterized by morphologic and functional changes that turn it into a source of cytokines directly produced by adipocytes. These are currently known as adipokynes,

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Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet–Fed Female Mice

Hypertension (2016)

Jaume Padilla Francisco I. Ramirez‐Perez Javad Habibi Benjamín C. Bostick Annayya R. Aroor

We recently showed that Western diet-induced obesity and insulin resistance promotes endothelial cortical stiffness in young female mice. Herein, we tested the hypothesis that regular aerobic exercise would attenuate the development of endothelial and whole artery stiffness in female Western diet-fed mice. Four-week-old C57BL/6 mice were randomized into sedentary (ie, caged confined, n=6) or regular exercise (ie, access to running wheels, n=7) conditions for 16 weeks. Exercise training improved glucose tolerance in the absence of changes in body weight and body composition. Compared with sedentary mice, exercise-trained mice exhibited reduced endothelial cortical stiffness in aortic explants (sedentary 11.9±1.7 kPa versus exercise 5.5±1.0 kPa; P<0.05), as assessed by atomic force microscopy. This effect of exercise was not accompanied by changes in aortic pulse wave velocity (P>0.05), an in vivo measure of aortic stiffness. In comparison, exercise reduced femoral artery stiffness in isolated pressurized arteries and led to an increase in femoral internal artery diameter and wall cross-sectional area (P<0.05), indicative of outward hypertrophic remodeling. These effects of exercise were associated with an increase in femoral artery elastin content and increased number of fenestrae in the internal elastic lamina (P<0.05). Collectively, these data demonstrate for the first time that the aortic endothelium is highly plastic and, thus, amenable to reductions in stiffness with regular aerobic exercise in the absence of changes in in vivo whole aortic stiffness. Comparatively, the same level of exercise caused destiffening effects in peripheral muscular arteries, such as the femoral artery, that perfuse the working limbs.

Aerobic Exercise

10.1161/hypertensionaha.116.07954

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Citations (33)