To evaluate the feasibility and efficacy of sequential neoadjuvant chemotherapy, chemoradiation, and surgery in patients with locally advanced esophageal cancer.There were 29 patients who received paclitaxel 150 mg/m2 and gemcitabine 3000 mg/m2 2 weeks apart. Two weeks later, patients received cisplatin 75 mg/m2 and 5-fluorouracil (5-FU) 1000 mg/m2/d continuous infusion for 4 days with concurrent radiotherapy in 15 fractions to a total dose of 4000 cGy. After 6 weeks, cisplatin and 5-FU were repeated at the above doses. After 4 to 6 weeks, patients were restaged and underwent surgical resection.All 29 patients completed the prescribed gemcitabine, paclitaxel, and radiation therapy. Febrile neutropenia occurred in 1 patient and 4 patients received growth factor support. After neoadjuvant treatment, 1 patient refused surgery, 23 underwent R0 resection (82%), while 5 developed progressive disease. Four patients developed anastomotic leaks (17%). Four patients had complete pathologic responses (14%) and 4 (14%) had only residual microscopic disease. Nine patients remain alive at a median follow-up of 48 months. Three-year survival for the entire cohort was 36%.This regimen was associated with a high rate of compliance and induction therapy had an acceptable toxicity profile. The R0 resection rate and 3-year survival data are similar to recently reported studies. While active, gemcitabine and paclitaxel induction therapy was associated with an increased rate of postoperative complications, but no increase in survival. Patterns of failure continue to demonstrate the need for regimens incorporating greater emphasis on systemic therapy for locally advanced esophageal cancer.
The location of a burn injury may impact the psychosocial recovery of burn injured patients. Limited data exist on the health-related quality of life (QoL) for children who sustain burn injuries involving the face. The purpose of this study was to analyze the effects of facial burn injuries on the QoL of children 5–18 years of age. Two validated Burn Outcomes Questionnaires, one completed by the parent and the other by the child (11–18) were administered at two regional pediatric burn centers at the first clinic appointment post discharge and at 3, 6, 12, 18, and 24 months thereafter. Comparisons were made between children who did and did not sustain facial burns, as well as between children with facial burns who did and did not wear pressure garments or masks. The location of the facial burn was included in the analysis. Statistical significance was determined by Student's t-test. Fifty-four parents...
