Tibial motor nerve conduction velocity was measured in rats, before and two months after the induction of diabetes with streptozotocin. A second group of diabetic animals was also administered 1% dietary myoinositol supplements. An analysis of variance was performed on these data. Myoinositol supplements had no effect whatsoever. The period of diabetes had a statistically significant and quantitatively marginal effect (a decrease of 2.2 m s-1) on conduction velocity. This is considerably less than in previous reports. The reasons for this are discussed. Tibial motor nerve conduction velocity was also measured in a group of alloxan-diabetic rabbits two months after the induction of diabetes and in an age-matched control group. Conduction velocity was again slightly but significantly less in the diabetic animals.
King R.H.M., Thomas P.K. & Pollard J.D. (1977) Neuropathology and Applied Neurobiology 3, 471486 Axonal and dorsal root ganglion cell changes in experimental allergic neuritis Observations have been made on experimental allergic neuritis in guinea pigs induced by the inoculation of rabbit sciatic nerve combined with Freund's adjuvant. Axonal lesions were observed most often in the later stages of the acute disease and in animals with a chronic relapsing course. They consisted of axonal interruption and regeneration, and ‘reactive’ axonal changes in demyelinated and remyelinated fibres, and in fibres of normal appearance that may have possessed lesions at some other point along their course. Abnormalities were not detected in anterior horn cells. Loss of dorsal root ganglion cells was rare, but invasion of the cells by lymphocytes which were present within large intracellular vacuoles, was at times conspicuous. The axonal and dorsal root ganglion cell changes may represent a ‘bystander’ effect in a cell‐mediated delayed hypersensitivity reaction.
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