Abstract Funding Acknowledgements Type of funding sources: None. Background Accumulated data suggest that low glycemic index diet (LGID) improved several clinical and biochemical parameters in patients with atherosclerotic coronary artery disease (ASCAD) after percutaneous coronary interventions (PCI) [1]. Aim of the present study was to evaluate the influence of LGID on short-term clinical outcomes in patients with ASCAD. Material and Methods The prospective, open label randomized study included 160 ASCAD patients collected within 2016-2019 years (Aged 38-76 years, mean age 58.2±12.0 years, male=48%). Patients were divided into 2 groups by 80 and assigned either LGID or routine recommended diet (RD). Patients were followed-up to three years after the PCI followed by stenting (medium 18.22±6.54 months) for the assessment of major adverse cardiac events (MACE). All data analyzed using STATA software. Results At the follow up period mortality rate was higher in RD groups than LGID group (RR1.34, CI 95%, 1.025-1.85, P<0.05). MACE were significantly higher in Group II than Group I patients (RR 1.28, CI 95%, 1.018-1.76, P<0.05). During the follow up 7% of patients occurred ACS whereas 11% patients in RD group occurred ACS (P<0.05). Regarding the stent thrombosis, there were not observed statistically significant changes between groups (P>0.05). Target vessel revascularization were performed in 2.5% LGID group patients whilst 6.25% in RD group patients (P<0.05). Besides, target lesion revascularization was performed in 1.25% LGID patients whilst 3.75% RD group patients (P<0.05). When we analyzed clinical outcomes by gender there were not observed any statistically significant changed between men and women (P>0.05). Conclusion Low glycemic index diet had lesser risk of MACE than routine diet in the short-term period in patients with atherosclerotic coronary artery disease after PCI. Further studies are required with large amount of patients.
Abstract Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data from the 2001 Euro Heart Survey. Methods and results Patients (n = 3116) aged over 18 years with a diagnosis of IE based on the ESC 2015 IE diagnostic criteria were prospectively identified between 1 January 2016 and 31 March 2018. Individual patient data were collected across 156 centres and 40 countries. The primary endpoint is all-cause mortality in hospital and at 1 year. Secondary endpoints are 1-year morbidity (all-cause hospitalization, any cardiac surgery, and IE relapse), the clinical, epidemiological, microbiological, and therapeutic characteristics of patients, the number and timing of non-invasive imaging techniques, and adherence to recommendations as stated in the 2015 ESC Clinical Practice Guidelines for the management of IE. Conclusion EURO-ENDO is an international registry of care and outcomes of patients hospitalized with IE which will provide insights into the contemporary profile and management of patients with this challenging disease.
One of the promising areas of treating cardiovascular diseases is the use of drugs with metabolic action. Metabolic drugs have not only the ability to improve myocardial energy metabolism, but also strong antioxidant properties.
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