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    The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry
    Gilbert HabibPatrizio LancellottiP A ErbaAnita SadeghpourMarwa Sayed MeshaalAntonia SambolaShumaila FurnazRodolfo CitroJulien TernacleErwan DonalBernard CosynsBogdan A. PopescuBernard IungBernard PrendergastCécile LarochePilar TornosMichal PazderníkAldo P. MaggioniChris P GaleNora Nabila Ali Tatar-ChentirMouaz H. Al‐MallahMeriam Åström AneqGeorge AthanassopoulosLuigi P. BadanoS. BenyoussefErick Calderón-ArandaNuno CardimKL ChanBernard CosynsIsabel CruzThor EdvardsenGeorg GoliaschGilbert HabibAndreas HagendorffKrasimira HristováBernard IungOtto KampD-H KangWilliam KongС.Т. МацкеплишвилиMarwa Sayed MeshaalM MirocevicAleksandar NeškovićMichal PazderníkEdyta Płońska‐GościniakBogdan A. PopescuBernard PrendergastMaha RaissouniRicardo RonderosLeyla Elif SadeAnita SadeghpourAntonia SambolaShantanu P. SenguptaJ Separovic-HanzevackiMasami TakeuchiEdwin S. TucayAna Clara Tude RodriguesAndréa VargaJ. VaskelyteKazufumi YamagataK YiangouH. ZakyIsabel GranadaM MahiaS RessiFrancisco NacinovichAna C Lavilla IribarrenP. Fernandez OsesGustavo AveglianoEduardo FilipiniRamón De la Cruz ObregónM BangherJ DhoL CartasegnaM. PlastinoV NovasC ShigelGraciela ReyesLurdes SantosNatalio GastaldelloM Granillo FernandezM PotitoGisela StreitenbergerP VelazcoJosé CasabéClaudia CortésEduardo GuevaraFabián SalmoM SeijoF WeidingerMaria HegerRenee L. BrooksClaudia StöllbergerCarolyn Y. HoLeonard PerschyL PuskasChristian BinderRaphaël RosenhekM SchneiderMP WinterE HofferM MelissopoulouE LecoqD. LegrandSandrine JacquetM MassozLuc PiérardStella MarchettaRaluca DulgheruC. D ́EmalCécile OurySteven DroogmansD. KerkhoveD. PleinL SoensCaroline WeytjensAndreea MotocBram RoosensI LemoineInez RodrigusBernard P. PaelinckBram J. AmselPhilippe UngerDéborah KonopnickiC. BeauloyeAgnès PasquetJean‐Louis VanoverscheldeS PierardDavid VancraeynestF SinnaeveJosé Lázaro AndradeKamila Fernanda StaszkoR Dos Santos MonteiroMarcelo Haertel MiglioranzaD. L. ShuhaM AlcantaraV CravoL FazzioAna FélixM IsoC MusaAna Paula dos Reis Velloso SicilianoFábio Villaça Guimarães FilhoAna Clara Tude RodriguesF VilelaJuarez R. BragaR SilvaDaniela Laranja Gomes RodriguesL SilvaSamira Saady MorhyCláudio Henrique FischerR SilvaMarcelo Luiz Campos VieiraT. AfonsoJ. AbreuSandra Nívea dos Reis Saraiva FalcãoValdir Ambrósio MoisésAgostinho Pinto GouvêaFrederico MancusoAna Carolina Mello Fontoura de SouzaC Y SilvaG JoãoCely Saad AbboudRodrigo Bellio de Mattos BarrettoA RamosRenato Tambellini ArnoniJorge Eduardo AssefDorival Júlio Della TognaDavid Le BihanL. MiglioliA P Romero OliveiraRoberto Tadeu Magro KrollDaniel CortezCláudio Léo GelapeM d C Peirira NunesTeresa Cristina Abreu FerrariKevin A. HayV. LeMathieu PageFrédéric PoulinClaude SauvéKarim SerriChantal MercureJ BeaudoinPhilippe PîbarotIgal A. SebagLawrence RudskiG RicafortBruno BaršićVladimir KrajinovićMartina VargovićDaniel LovrićV Reskovic-LuksicJosip VinceljSandra Jakšić JurinjakV YiannikouridesMarios IoannidesC PofaidesV MasouraJiří PudichAleš LinhartMichal ŠiranecJ MarekK BlechovaMirt KamenikRadek PelouchZdeněk CoufalM MikulicaMartin GřivaEva JančováM. MikulcovaMiloš TáborskýJan PřečekMarkéta JečmenováJ. LatalJ WidimskýT. ButtaS MachacekR. VancataJindřich ŠpinarMária HolickáF Pow Chon LongN AnzulesArturo CarpioG LargachaErnesto PeñaherreraDavide MoreiraE MahfouzE ElsaftyAmel M. SolimanYazan ZayedJ AbouleneinM Abdel-HayAbdallah AlmaghrabyMahmoud AbdelnabyMustafa I. AhmedBasma HammadYehia SalehHatice S. ZahranO ElgebalyAly M A SaadMohammed AliA ZeidReham El SharkawyA Al KholyRamy DossDina OsamaHussien RizkA ElmogyM MishrikyPatrick AssayagSafwane El HatimiS. HubertJ-P CasaltaFrédérique GourietFlorent ArregleSerge CammilleriL. TessonnierAlberto RibériÉlisabeth Botelho-NeversAmandine Gagneux‐BrunonRomain PierrardC. 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ChirouzeKévin BouillerLaurent Hustache‐MathieuTimothée KlopfensteinJ MoreauPierre‐Edouard FournierA S BrunelPitt LimLéopold OliverJulien TernacleAmina MoussafeurP. ChavanetLionel PirothArnaud Salmon‐RousseauM. BuissonSophie MahyCarolina Castro MartinsSandrine GohierOlivier AxlerFlorian BaumannS LebrasC. PiperDenise GuckelJochen BörgermannDieter HorstkotteEliane Roseli WinkelmannB BrockmeierDouglas GreyGeorg NickenigRobert SchuelerCihat ÖztürkElisabeth StöhrChristian W. HammThomas WaltherReynaldo André BrandtA-C FrühaufChristine HartungClara HellnerC. WildMiriam BeckerSatoshi HamadaW. KaestnerKarl StanglFabian KnebelGerd BaldenhoferAnna BrechtHenryk DregerC IsnerFrieder PfäfflinMiriam StegemannRalf ZahnB. FraitureCaroline KilkowskiA-K KarcherS KlingerH TolksdorfDimitris TousoulisConstadina AggeliSkevos SiderisErifili VenieriG. SarriDimitris TsiaprasI ArmenisA KoutsiariG FlorosC. GrassosStylianos DragasisLοukianos S. RallidisCharalampos VarlamosLampros K. MichalisKaterina Κ. NakaAris BechlioulisAnna KotsiaΛάμπρος ΛάκκαςΚωνσταντίνος ΠαππάςConstantinos PapadopoulosS KiokasAthina LioniS MisailidouJohn BarbetseasΜaria BonouChris J. KapeliosI TomprouKanella ZervaAthanasios ManolisE. HamodrakaDimitrios AthanasiouG HaralambidisH SamarasPitt LimA NagyAndrea BartykowszkiEdit GaraKunda MungulmareRavi R. KasliwalManish BansalS RanjanA BhanMajid KyavarMajid MalekiF Noohi BezanjaniAzin AlizadehaslShabnam BoudaghA GhavidelPardis MoradnejadHamid Reza PashaBehshid GhadrdoostDan GilonJacob StrahilevitzMaor WanounouSarah IsraelCarlo D’AgostinoPaolo ColonnaLucrezia De MicheleF FumarolaM StanteN MarchionniValentina ScheggiB AlteriniStefano Del PacePierluigi StefànoClotilde SparanoN RuoziR TenagliaDenisa MuraruUgo LimbrunoAlberto CrestiPasquale BarattaMarco SolariCristina GiannattasioAntonella MoreoBenedetta De ChiaraBeatriz MonteroF MuscaC A OrceseFrancesca PanzeriF. SpanoClaudio RussoOttavio AlfieriMichele De BonisStefania ChiappettaBenedetto Del FornoMarco RipaPaolo ScarpelliniChiara Tassan DinBarbara CastiglioniRenée PasciutaSilvia CarlettiDavid FerraraMonica GuffantiGiuseppe IaciE. LapennaTeodora NisiChiara OltoliniElena BusnardoU. PajoroEustachio AgricolaRoberta MeneghinDavide SchiaviFederico PiscioneRodolfo CitroRossella Maria BenvengaLuigi GrecoL SorienteI RadanoCristina ProtaMichele BellinoDavide Di VeceFrancesco SantiniAntonio SalsanoGuido Maria OlivieriF TurriniRoberto MessoraStefano TondiAndreea OlaruVirginia AgnolettoL GrassiClaudia LeonardiS SansoniStefano del PonteGuglielmo Mario Actis DatoAndrea De MartinoNobuyuki OhteShohei KikuchiKazuaki WakamiKazutaka AonumaYu Bin SeoTomoko IshizuTomoko Machino‐OhtsukaMasae YamamotoN IidaHiromichi NakajimaYu NakagawaChisato IzumiMasashi AmanoMakoto MiyakeKosuke TakahashiIchiro ShiojimaYoko MiyasakaHirofumi MaebaYoshinobu SuwaNaoyuki TaniguchiSatoshi TsujimotoTakeshi KitaiMasao ÔtaSatoshi YudaS SasakiN HagiwaraKatrina Go YamazakiK AshiharaK AraiChihiro SaitouS SaitouG SuzukiYuichi ShibataNaoki WatanabeShun NishinoKohei AshikagaNagato KuriyamaKeitaro MaharaTakashi OkuboH FujimakiHidemasa ShitanHaruko YamamotoKyohei AbeM TeradaShuichiro TakanashiMasafumi SataHirotsugu YamadaKenya KusunoseYasuaki SaijoHaruo SenoYuichiro OheT OnishiFrancesco SeraSatoshi NakataniHiroya MizunoK. SengokuS W ParkK Eun KyoungL. Ga YeonJ-w HwangC Jin-OhSung Jin ParkL Sang-CholC Sung-ASe Yong JangRan HeoSak LeeJ-M SongE. JungJurgita PlisienėA DambrauskaiteG GruodyteRegina JonkaitienėVaida MizarienėJ AtkocaityteRūta ŽvirblytėRouguiatou SowA. CodreanuT. StaubC. MichauxE Chamorro-De VegaL Jacobs-OraziC. Mallia AzzopardiRobert G. XuerebT. PiscopoJames FarrugiaM FenechE PllahaCiro VellaDavid BorgRamon CashaL GribElena RaevschiGrejdieru AlexandraD KravcencoE PrisacariSamohvalov ElenaS SamohvalovN SceglovaE PanfileL CardaniucV CorceaA FeodoroviciV GainaL GirbuPavlina JimbeiG. BalanI CardaniucI BenescoV MarianN SumargaB BožovićNebojša BulatovićP LakovicLjilja MusićRicardo P.J. BuddeAli R. WahadatT GamelaThomas A. MeijersJoost P. van MelleVincent M. van DeursenHarry J.G.M. CrijnsS BekkersEmile C. CheriexM GilbersBas KietselaerChristian KnackstedtRoberto LorussoSimon SchallaSebastian A.F. StreukensSteven A.J. ChamuleauM-J CramerArco J. TeskeT Van der SpoelA WindJ LokhorstO LiesbekH Van HeusdenWilco TanisIvo van der BiltJoris W.J. VriendH De Lange-van BruggenE KarijodikoroRobert K. RiezebosElise van DongenJ SchoepV StolkJ OffstadJ O BeitnesThomas Helle-ValleHelge SkulstadRita SkårdalNadeem QamarShumaila FurnazBina AhmedM H ButtM F KhanzadaTahir SaghirA WahidTomasz HryniewieckiPiotr SzymańskiKarolina MarzecM Misztal-OgonowskaWojciech KosmalaMonika Przewłocka‐KosmalaAmanda RojekK WoznickaJ ZachwycAnna LisowskaM. KamińskaJarosław D. KasprzakEwelina KowalczykD F StrzeckaPaulina Wejner‐MikM TrabuloP FreitasSara RanchordásGabriel RodriguesPatrícia PintoCatarina QueirósJ AzevedoL MarquesDaniel SeabraLuísa Moura BrancoJ. AbreuMadalena Coutinho CruzA GalrinhoRita Ilhão MoreiraPedro RioAna Teresa TimóteoMafalda SelasVanda CarmeloBernardo NevesHélder PereiraAndrea GuerraA MarquesI PintassilgoMirela TomescuNelu-Mihai TrofenciucMinodora AndorA BordejevicH S BraneaFlorin Alexandru CăruntuL A VelceanAdelina MavreaMustafa ÖnelT ParvanescuDana PopAdina Pop-MoldovanM. I. PuticiuLiviu CirinIoana Mihaela CituCoralia CotoraciD DarabantiuR. FarcasIosif MarincuA. IonacDragoș CozmaCristian MornoşF GoantaI PopescuRuxandra BeyerRazvan O. MadaRaluca RanceaRaluca TomoaiaŞtefan Horia RoşianCristina StănescuZhanna KobalavaJ. KaraulovaE. O. KotovaA MiltoA. S. PisaryukN PovalyaevMaria SorokinaJamilah AlRahimiA ElshiekhAbdulrahman JamielAli AhmedN. AttiaB PutnikovicAndreja DimićBranislava IvanovićSnežana MatićDanijela TrifunovićJelena PetrovićD KosevicIvana StojanovićIvana PetrovićP DabicPredrag MilojevićIlija SrdanovićStamenko ŠušakLazar VelickiAleksandra VulinM KovacevićAleksandar RedžekMaja StefanovićTiong Cheng YeoWilliam KongKian Keong PohIsidre VilacostaC FerreraCarmen OlmosM Abd El- NasserFrancisco CalvoE Blanco-GonzalezM Bravo AmaroElena López-RodríguezJ Lugo AdanA. Nodar GermiñasPablo Pazos-LópezM. Pereira LoureiroMaria T. PerezSergio Raposeiras‐RoubínS Rasheed YasM.-M. Suarez-VarelaF. Vasallo VidalDavid García‐DoradoNúria Fernández-HidalgoTeresa González‐AlujasJ LozanoOlga MaisterraNatalia PizziRaquel RíosAntoni Bayés‐GenísL Pedro BotetNúria VallejoC LlibreLourdes MateuRamiro NúñezD QuesadaE. BerasteguiD Bosch PortellJaime AboalX BertránR Brugada TarradellasPablo Loma-OsorioC Tiron de LlanoMiguel Á. ArnauA. BelMarino BlanesA. OsaM AnguitaFernando CarrascoJuan C. CastilloJ. L. ZamoranoJosé Luis Moya MurM AlvaroCovadonga Fernández‐GolfínJuan Manuel Monteagudo RuizEnrique NavasMaría Carmen Fariñas ÁlvarezJ. Aguero BalbinJesús ZarauzaJ.F. Gutiérrez-DíezCarlos ArmiñanzasFrancisco Arnaíz de las RevillasA Arnaiz GarciaManuel Cobo BelausteguiMarta Fernández SampedroManuel CuadraL. Garcia CuelloClaudia González-RicoRegino RodríguezJosune GoikoetxeaMiguel MontejoJosé M. MiróManel AlmelaJuan AmbrosioniAsunción MorenoEduard QuintanaElena SandovalAdrián TéllezJ M TolosanaBàrbara VidalCarlos FalcesDavid FusterC Garcia-de-la-MariaMarta Hernández‐MenesesJuan LlopisFrancesc MarcoIsabel Ruíz-ZamoraAlfredo Bardajı́E. SanzGraciano García‐PardoMarta Guillén MarzoA Rodriguez OviedoA Villares JimenezLeïla AbidRania HammamiS. KammounMohamed Sami MouraliF. MghaiethManel Ben HlimaS. BoudicheS. OualiLilia ZakhamaS AntitI. 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    Abstract:
    Abstract Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data from the 2001 Euro Heart Survey. Methods and results Patients (n = 3116) aged over 18 years with a diagnosis of IE based on the ESC 2015 IE diagnostic criteria were prospectively identified between 1 January 2016 and 31 March 2018. Individual patient data were collected across 156 centres and 40 countries. The primary endpoint is all-cause mortality in hospital and at 1 year. Secondary endpoints are 1-year morbidity (all-cause hospitalization, any cardiac surgery, and IE relapse), the clinical, epidemiological, microbiological, and therapeutic characteristics of patients, the number and timing of non-invasive imaging techniques, and adherence to recommendations as stated in the 2015 ESC Clinical Practice Guidelines for the management of IE. Conclusion EURO-ENDO is an international registry of care and outcomes of patients hospitalized with IE which will provide insights into the contemporary profile and management of patients with this challenging disease.
    Keywords:
    Infective Endocarditis
    Clinical endpoint
    Clinical Practice
    Two cases of infective endocarditis are reported. In both, vegetations on the cardiac valves characteristic of endocarditis were documented by echocardiography and confirmed at surgery in one of them. The various features of vegetative endocarditis on the echocardiogram are described. Differentiation of these echoes from those produced by other morbid states is discussed. Echocardiography is considered a useful non-invasive technique in the diagnosis of infective endocarditis. Cardiac surgery is usually found to be necessary in addition to medical therapy, when echoes characteristic of vegetative endocarditis are recorded by echocardiography.
    Infective Endocarditis
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    BACKGROUND The term “predisposition” is used as an indication of antimicrobial prophylaxis to prevent infective endocarditis and as a criterion for diagnosing infective endocarditis according to the modified Duke criteria. The criterion for diagnosing infective endocarditis in native valves is not well defined. OBJECTIVES To identify conditions that increase the risk for infective endocarditis in native valves, for the diagnosis of infective endocarditis according to the modified Duke criteria. In parallel, we compared the results with the year of patient inclusion for each study and echocardiographic techniques. RESULTS Our systematic review included 207 studies published from January 1970 to August 2015. Studies that focused on mitral valve prolapse (112 studies), prior infective endocarditis (96) and bicuspid aortic valve (78) provided the most data. However, only six (5.3%), three (3.1%) and one (1.3%) of these studies, respectively, used analytical statistical methods. Three (2.7%), two (2.1%) and one (1.3%), respectively, were graded as good quality studies. Odds ratios (ORs) for developing infective endocarditis were 3.5–8.2 for mitral valve prolapse, and 2.2 and 2.8 for prior infective endocarditis. The hazard ratio for developing infective endocarditis was 6.3 for bicuspid aortic valve. The mean prevalence proportion of infective endocarditis in patients with these three heart conditions were 8.5% (mitral valve prolapse), 8.3% (prior infective endocarditis) and 8.8% (bicuspid aortic valve). The proportions of publications prior to the publication of the modified Duke criteria were 81.8, 75.6 and 74%, respectively. Evolution of the imaging method and echocardiographic technique was estimated to be considerable for mitral valve prolapse. The literature review on aortic valve stenosis (46 studies), mitral valve insufficiency (41) and aortic valve insufficiency (39) provided two analytical studies for aortic stenosis. One study was graded as good quality and reported a hazard ratio 4.9. The mean prevalence of these heart conditions in patients with infective endocarditis were 7.3, 19.9 and 10.2%, respectively. The proportions of publications prior to the publication of the modified Duke criteria were 78, 75.6 and 79.5%, respectively. The evolution of both the echocardiographic technique and the categorisation of valve disease severity was considerable for all three entities. CONCLUSIONS The evidence for native valve heart conditions predisposing to infective endocarditis is mainly based on studies with only descriptive statistics published prior to the release of the modified Duke criteria. Mitral valve prolapse, prior infective endocarditis and bicuspid aortic valve are frequently cited as predisposing heart conditions for infective endocarditis. The evolution in echocardiographic techniques over the past decades and its influence on diagnosis was considerable for mitral valve prolapse, aortic stenosis, mitral insufficiency and aortic insufficiency.
    Infective Endocarditis
    Mitral valve prolapse
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    Despite advances in diagnosis and treatment, infective endocarditis still shows considerable morbidity and mortality rates. The dermatological examination in patients with suspected infective endocarditis may prove very useful, as it might reveal suggestive abnormalities of this disease, such as Osler’s nodes and Janeway lesions. We report a case of a women with infective endocarditis and the typical cutaneous manifestations. Despite advances in diagnosis and treatment, infective endocarditis still shows considerable morbidity and mortality rates. The dermatological examination in patients with suspected infective endocarditis may prove very useful, as it might reveal suggestive abnormalities of this disease, such as Osler’s nodes and Janeway lesions. We report a case of a women with infective endocarditis and the typical cutaneous manifestations.
    Infective Endocarditis
    Etiology
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    Despite advances in diagnosis and treatment, infective endocarditis remains a dangerous disease, particularly for people at risk because of a prosthetic valve, congenital heart disease, or a history of infective endocarditis, in whom morbidity and mortality approach 50%. 1 Prendergast BD The changing face of infective endocarditis. Heart. 2006; 92: 879-885 Crossref PubMed Scopus (216) Google Scholar Antibiotic prophylaxis for such patients at the time of invasive procedures has been a tenet of cardiac and dental practice for half a century, although the evidence of benefit is limited. Few cases of infective endocarditis are now secondary to oral streptococci, and Staphylococcus aureus (frequently acquired as a result of nosocomial infection or misuse of intravenous drugs) is now the most common pathogen, with attendant higher mortality. 2 Moreillon P Que Y-A Infective endocarditis. Lancet. 2004; 363: 139-149 Summary Full Text Full Text PDF PubMed Scopus (830) Google Scholar
    Infective Endocarditis
    Epidemiology of Infective Endocarditis. Microbiology of Infective Endocarditis and Clinical Correlates: Gram-positive Organisms. Microbiology of Infective Endocarditis and Clinical Correlates: Gram-negative and Other Organisms. Pathology. Pathoanatomical, Pathophysiological and Clinical Correlations.Clinical Manifestations of Native Valve Endocarditis. Endocarditis in Intravenous Drug Abusers. Prosthetic Valve Endocarditis. Infective Endocarditis of Intracardiac Devices. Nosocomial and Healthcare Associated Infective Endocarditis. Infective Endocarditis of Immunocompromised Patients. Diagnosis I. Diagnosis-Echocardiography II. Medical Management of Infective Endocarditis. Surgical Management of Infective Endocarditis. Prophylaxis. Mimics of Infective Endocarditis
    Infective Endocarditis
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    This chapter contains sections titled: Predisposing Cardiac Lesions Portals of Entry Organisms Responsible Diagnosis and Physical Signs Treatment Management Other Interventions and Infective Endocarditis Prevention of Infective Endocarditis Non-infective Endocarditis
    Infective Endocarditis
    HACEK endocarditis
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