Sadaaki Yamazoe

Osaka City University

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Ryosuke Amano

Osaka City University

Kosei Hirakawa

Osaka City University

Masaichi Ohira

Baba Memorial Hospital

Kenjiro Kimura

Osaka Metropolitan University

Kazuya Muguruma

Osaka City University

Hiroaki Tanaka

Fuchu Hospital

Go Ohira

Tokyo Metropolitan University

Kiyoshi Maeda

Osaka Metropolitan University

Hisashi Nagahara

Japan Society of Laparoscopic Colorectal Surgery

Masatsune Shibutani

Osaka Metropolitan University

Cooperative Institutions

Osaka City University

137

Osaka Metropolitan University

Osaka City General Hospital

Tokyo Metropolitan University

Osaka City University Hospital

Metropolitan University

Osaka University

Kashiwa Municipal Hospital

Sumitomo Hospital

Fuchu Hospital

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[A Patient with Recurrent Ulcerative Colitis-Associated Rectal Cancer Attaining a Complete Response with FOLFIRI plus Bevacizumab].

PubMed (2015)

Yasuhito Iseki Kiyoshi Maeda Masatsune Shibutani Hisashi Nagahara Tetsuro Ikeya

A 60-year-old man underwent laparoscopic total proctocolectomy with ileostomy for advanced ulcerative colitis-associated rectal cancer. The final diagnosis was advanced cancer pT3, pN2 and M0 (pStage Ⅲb). Adjuvant therapy with XELOX was performed. However, abdominal CT revealed a liver metastasis and lymph node metastases in the pelvis 6 months after surgery. The patient was treated with FOLFIRI plus bevacizumab. After 20 courses of chemotherapy, the patient was considered to have experienced a clinical CR, which has been maintained for 3 years 5 months.

FOLFIRI

Proctocolectomy

Ileostomy

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Pancreatectomy with major arterial resection after neoadjuvant chemoradiotherapy gemcitabine and S-1 and concurrent radiotherapy for locally advanced unresectable pancreatic cancer

Surgery (2015)

Ryosuke Amano Kenjiro Kimura Bunzo Nakata Sadaaki Yamazoe Hisashi Motomura

Chemoradiotherapy

Arterial Embolization

10.1016/j.surg.2015.02.016

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Citations (45)

Efficacy of Transhepatic Anterior Approach to the Inferior Vena Cava for Malignant Pheochromocytoma Invading Right Posterior Lobe of the Liver: A Case Report

International Surgery (2018)

Gen Tsujio Kenjiro Kimura Yukie Tauchi Go Ohira Ryosuke Amano

Introduction: The anterior approach to the inferior vena cava (IVC) by the liver hanging maneuver is effective in resecting large retrohepatic tumors without mobilizing the right lobe. Case presentation: A 50-year-old man was referred to our hospital with a diagnosis of pheochromocytoma. He had severe congestive heart failure and cardiac ejection fraction was 15%. Abdominal magnetic resonance imaging (MRI) and ultrasonography (US) showed an adrenal mass about 80 mm in diameter. The tumor-infiltrated posterior segment of the right hepatic lobe and tumor were widely attached to the IVC. After treatment of congestive heart failure with conservative therapy, surgery was planned. Right adrenectomy and right hepatectomy were performed, the latter using the liver hanging maneuver to avoid mobilizing the right lobe, and we were able to minimize blood pressure fluctuations and perform the operation safely. The histopathologic diagnosis was malignant pheochromocytoma. Conclusions: We performed right hepatectomy without mobilizing the right lobe by the liver hanging maneuver and minimized stimulation of the tumor. We could perform the operation safely using the liver hanging maneuver, which seems effective in such cases.

Lobe

Abdominal ultrasonography

10.9738/intsurg-d-17-00130.1

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Citations (1)

Impact of laparoscopic liver resection for hepatocellular carcinoma on the development of postoperative complication

日本肝胆膵外科学会学術集会(Web) (2019)

Ito Tokuji Hiroji Shinkawa Takemura Shigekazu Ryosuke Amano Tanaka Shogo

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Laparoscopic liver resection for treating recurrent hepatocellular carcinoma

Journal of Hepato-Biliary-Pancreatic Sciences (2013)

Akishige Kanazawa Tadashi Tsukamoto Sadatoshi Shimizu Shintaro Kodai Satoshi Yamamoto

Abstract Background It is still unknown whether laparoscopic liver resection is suitable for recurrent hepatocellular carcinoma (HCC) after previous curative hepatic resection. Method The perioperative outcomes of 40 patients treated with second surgery for recurrent HCC by partial hepatectomy were studied retrospectively. The second surgery was performed under laparotomy in 20 patients (laparotomy group) and under laparoscopy in 20 patients (laparoscopy group). Results Intraoperative blood loss ( p < 0.0001) and the incidence of postoperative complications ( p = 0.0004) were lower in the laparoscopy group than in the laparotomy group. The incidence rates of surgical site infection and intractable ascites were significantly higher in the laparotomy group than in the laparoscopy group ( p = 0.0202, p = 0.0436, respectively). The proportion of patients classified as Clavien grade IIIa was higher in the laparotomy group than in the laparoscopy group ( p = 0.0033). The duration of the postoperative hospital stay was significantly shorter in the laparoscopy group than in the laparotomy group ( p < 0.0001). Conclusions Postoperative morbidity has been decreased by the introduction of laparoscopic liver resection in patients with recurrent HCC after curative hepatic resection. As a result, the duration of the postoperative stay is shorter.

10.1007/s00534-012-0592-9

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Citations (70)

[Five cases of severe radiation pneumonitis after chemoradiotherapy for esophageal cancer].

PubMed (2013)

Katsunobu Sakurai Naoshi Kubo Masatsune Shibutani Sadaaki Yamazoe Kenjiro Kimura

Chemoradiotherapy( CRT) for esophageal cancer is a useful modality for both locally advanced and resectable cases. Among adverse events related to CRT, radiation pneumonitis( RP) requires special attention because it has been shown to be occasionally associated with a worse acute prognosis. We report 5 cases of severe RP after CRT. All patients were male, and their mean age was 72 years (range: 66-76 years). The clinical stage of esophageal cancer was I in 1 case, II in 2 cases, and IVa in 2 cases. The mean total radiation dose was 51.8 Gy (range: 43.4-61.4). Initial symptoms and first abnormal findings were a high fever in 4 cases and elevated serum C-reactive protein( CRP) levels in 1 case. No patients presented with respiratory symptoms, including dyspnea and coughing, as initial symptoms. All cases were diagnosed as RP by chest computed tomography examination, an average of 6.8 days after the completion of RT. Four patients required intensive care and were put on ventilator support. All patients received steroid pulse therapy. Two patients recovered from RP; however, 3 died( 1 attributable to multi-organ failure and 2 to respiratory failure). It is important to consider RP caused by CRT when patients present with high fever or elevated CRP levels after the completion of RT for esophageal cancer.

Pneumonitis

Chemoradiotherapy

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Establishment of a Liver Transplant Patient-derived Tumor Xenograft (PDX) Model Using Cryopreserved Pancreatic Ductal Adenocarcinoma

Anticancer Research (2020)

Ryota Tanaka Ken Kageyama Kenjiro Kimura Shinpei Eguchi Jun Tauchi

Background/Aim: There is rapid progression and widespread use of patient-derived tumor xenografts (PDX) in translational pancreatic cancer research. This study aimed to establish a liver transplant PDX model using cryopreserved primary pancreatic ductal adenocarcinoma (PDAC). Patients and Methods: Primary PDAC from 10 patients were cryopreserved and transplanted into immunodeficient mice using the liver pocket method. H&E staining and immunohistochemical staining, such as Ki-67, p53, Smad4, and MUC1 were used to evaluate engraftment and histological similarities. Results: Patient-derived xenograft placement was successful in six cases (60%), and 10 mice (33.3%). The Ki-67 index of primary PDAC and the cryopreservation duration were significantly related to successful engraftment (p=0.003 and p=0.007, respectively). Conclusion: In this study, we succeeded in establishing a liver transplant PDX mouse model as a preclinical platform. The successful engraftment was affected by the cryopreservation duration and could be detected by the Ki-67 index.

Liver Cancer

10.21873/anticanres.14234

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Citations (4)

Spontaneous Rupture of Pancreatic Acinar Cell Carcinoma: Report of a Case

International Surgery (2021)

Sadaaki Yamazoe Ryosuke Amano Kenjiro Kimura Go Ohira Kohei Nishio

Introduction Pancreatic acinar cell carcinoma (ACC) is a relatively rare neoplasm. Furthermore, tumor rupture is extremely rare. Only 1 case of ruptured pancreatic ACC has been reported, and the long-term outcome of the case is unknown. Here, we present a case of spontaneously ruptured ACC with long-term survival after successful resection. Case Presentation A 67-year-old man was brought to our hospital by ambulance, presenting with progressive left abdominal pain. Laboratory data showed an increased inflammatory response, and contrast-enhanced computed tomography showed a mass in the pancreas tail with nonuniform enhancement in the early phase. Fluid collection was detected around the spleen to the left kidney. Spontaneous rupture of a pancreatic tumor was strongly suspected. After improvement of his general condition, the patient underwent resection of the pancreas and adjacent organs. The resected tumor was surrounded by organs and adipose tissue, so obvious exposure was not observed in the surgical margins. Pathologically, neither exposure of tumor cells at the surgical margins nor lymph node involvement was detected. The patient has survived 80 months since initial diagnosis without any evidence of recurrence. Conclusion Although ruptured pancreatic ACC has the potential for dissemination, surgical resection including adjacent organs remains an option for curative treatment.

Pancreatic tumor

10.9738/intsurg-d-15-00207.1

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Predictive Factors for Change of Diabetes Mellitus Status After Pancreatectomy in Preoperative Diabetic and Nondiabetic Patients

Journal of Gastrointestinal Surgery (2014)

Keiichiro Hirata Bunzo Nakata Ryosuke Amano Sadaaki Yamazoe Kenjiro Kimura

10.1007/s11605-014-2521-5

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Citations (37)

A case of perforation of a pancreatic duct by a pancreatic stent during chemoradiotherapy for pancreatic head cancer: a case report

Surgical Case Reports (2019)

Takuya Mori Go Ohira Kenjiro Kimura Sadaaki Yamazoe Ryosuke Amano

Pancreatic injuries are rare, and no treatment plan has yet been established for grade III injuries. In many cases, pancreatic stent placement has resulted in saving patients. However, some cases of perforation of a pancreatic duct during the placement of a stent have been described, and there are also a few cases of delayed perforation by a pancreatic stent. A 62-year-old man had obstructive jaundice and pancreatitis due to locally advanced pancreatic head cancer. Both biliary and pancreatic stent were placed by endoscopy, after which chemoradiotherapy was performed. Four months later, he visited our hospital with severe abdominal pain. We performed enhanced CT and diagnosed the patient as having a perforation of a pancreatic duct by a pancreatic stent; therefore, we performed an emergency operation. Since we deemed pancreatectomy risky, we inserted pancreatic tubes into both sides of the perforated site and performed percutaneous transgastric drainage. The postoperative course was uneventful. We thereafter cut the tubes and switched to internal drainage. Many cases of pancreatic injuries have reported that pancreatic stent placement results in saving the patient, but there have been few cases in which a pancreatic stent causes perforation of a pancreatic duct. External drainage by pancreatic tubes is very effective in resolving perforation of a pancreatic duct.

Perforation

10.1186/s40792-019-0571-3

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