Background: Splenic steal syndrome (SSS) is a condition that can occur after orthotopic liver transplant (OLT). However, limited information is available about this condition.
This study aimed to investigate the expression and clinical significances of long noncoding RNA-ATB (lncRNA-ATB) in papillary thyroid cancer (PTC), and to explore the roles of lncRNA-ATB in PTC cell proliferation and migration.The expression of lncRNA-ATB in 64 PTC tissues and paired adjacent noncancerous thyroid tissues was measured. The association between lncRNA-ATB expression and clinicopathological characteristics was analyzed by Pearson X2. The diagnostic value of lncRNA-ATB was evaluated by receiver operating characteristic curve (ROC) analyses. The effects of lncRNA-ATB on PTC cell proliferation were evaluated by Cell Counting Kit-8 assays and Ethynyl deoxyuridine incorporation assays. The effects of lncRNA-ATB on PTC cell migration were evaluated by transwell assays.LncRNA-ATB is upregulated in PTC tissues compared with noncancerous tissues. LncRNA-ATB is also increased in PTC cell lines compared with normal thyroid follicular epithelial cell line. High-expression of lncRNA-ATB is associated with large tumor size and lymph node metastasis. ROC analyses revealed that lncRNA-ATB could sensitively discriminate PTCs from noncancerous tissues, as well as discriminating PTCs with lymph node metastasis from those without lymph node metastasis. Functional experiments showed that depletion of lncRNA-ATB significantly inhibits PTC cell proliferation and migration.LncRNA-ATB is upregulated and functions as an oncogene in PTC. Furthermore, lncRNA-ATB may serve as a diagnostic biomarker and therapeutic target for PTC.
Objective: To discuss the relationship between uncultivated pathogenic bacteria and periodontitis. Subjects and methods: Specific polymerase chain reaction (PCR) primers were designed for phylotypes AU126 and X112; PCRs were applied to determine the prevalence of these phylotypes in 35 patients with chronic periodontitis, 26 patients with plaque‐induced gingivitis and 20 healthy control subjects. Results: The specificity of each primer is validated on the basis of the results from sequence analysis of PCR products. AU126 and X112 were detected in the subgingival plaque samples in all the three groups. The prevalence of AU126 in subgingival plaque in chronic periodontitis (77.1%) and plaque‐induced gingivitis (61.5%) is relatively higher than that in the healthy subjects (10.0%), and the difference is statistically significant ( P < 0.01). The prevalence of X112 in subgingival plaque in periodontitis patients (85.7%) is higher than that in healthy subjects (30.0%), the difference ( P < 0.01) being equally statistically significant. The difference between the chronic periodontitis group and the plaque‐induced gingivitis group (50.0%) is statistically significant ( P < 0.05). Conclusions: It might be assumed that the novel uncultivated AU126 phylotype could possibly be related to chronic periodontitis and plaque‐induced gingivitis, and that X112 might play a role in the progress of lesion from gingivitis to periodontitis.
Objective
To analyze the imaging characteristics of contrast-enhanced ultrasound(CEUS) and dynamic contrast enhanced magnetic resonance imaging (CEMRI) for diagnosis of hepatic epithelioid hemangioendothelioma, and to increase the accuracy of diagnostic imaging.
Methods
The imaging characteristics of CEUS and dynamic CEMRI in 11 patients with hepatic epithelioid hemangioendothelioma confirmed by surgical pathology or fine needle aspiration biopsy were retrospectively analyzed.
Results
On conventional ultrasound, 14 lesions in 11 patients showed hypoechoic. The peripheral blood flow was detected in most patients by color Doppler flow imaging and the average resistant index was 0.62±0.05. During the arterial phase, 6 lesions showed diffuse enhancement, 6 lesions showed annular enhancement and 2 lesions showed branch enhancement.As to time of peak enhancement, compared to the normal hepatic parenchyma, hypoenhancement, isoenhancement and hyperenhancement were observed in 1 lesion, 7 lesions and 6 lesions respectively. Synchronous enhancement was observed in 8 lesions on contrast-enhanced ultrasound, rapid enhancement was observed in 5 lesions and slow enhancement was observed in 1 lesion and all lesions decreased quickly in portal phase and delayed phase. On CEMRI, all lesions showed low signal on TIWI, high signal on T2WI and DWI. There were 5 lesions showed obvious annular constant enhancement and 1 lesion showed obvious annular progressive enhancement. Progressive peripheral enhancement and fully filling in delayed phase were found in 4 lesions.While progressive peripheral enhancement and incompletely filling in delayed phase were found in 3 lesions. One lesion displayed constant enhancement and incompletely filling in delayed phase. Halo sign , lollipopsign , capsular retraction sign and vessel sign were appeared in 6, 7, 8 and 8 patients respectively.
Conclusions
Both contrast-enhanced ultrasound and CEMRI have characteristic manifestations for the diagnosis of hepatic epithelioid hemangioendothelioma and cominbing them would be great significance to improve the preoperative diagnostic accuracy.
Key words:
Contrast-enhanced ultrasound; Contrast-enhanced magnetic resonance imaging; Liver neoplasms; Hemangioendothelioma, epithelioid
To study the clinical effect of osteotome sinus floor elevation (OSFE) combined with simultaneous implant placement in the treatment of edentulous posterior maxilla subject to insufficient bone height in the periodontally compromised patients.Forty-seven Straumanns implants were placed in the posterior maxilla in 35 patients with the procedure of OSFE. The final prostheses were restored after 3 to 6 months. The follow-up period was 6 to 30 months. Radiographs were taken and PD, PLI, BOP were measured and analyzed.The overall survival rate was 95.74% during the study period. Forty-five out of the 47 implants were clinically stable and loaded without pain or any subjective sensation. The perforation ratio of the membrane was 4.26%. The average of PD around the implants was (3.22±1.07) mm. The average of the marginal bone loss was (1.38±0.59) mm.OSFE without bone graft proves to be an effective and predictable treatment for atrophic edentulous posterior maxillary region in patients with periodontitis, but the long-term effect needs further observation.
Abstract Introduction The traditional way to treat maxillary edentulous Cawood and Howell Class 4 (CH4) patients who exhibit the knife‐edge ridge form of edentulous jaws that are adequate in height and inadequate in width is extensive autologous bone grafting for conventional implant placement. Purpose To evaluate the feasibility of the zygomatic implant (ZI) quad approach in edentulous CH4 patients who presented a knife‐edge ridge form in the anterior maxilla for immediate loading. Material and methods Eligible patients with maxillary CH4 edentulism treated with the ZI quad approach were enrolled. Bone reduction and implant placement were performed under the guidance of a navigation system according to preoperative planning. The outcome variable was the implant survival rate, and additional variables were the ratio of immediate loading, complications and the relationship of the zygomatic implant path to the sinus wall. Statistical analysis was performed with the SAS statistical package. Results Fifteen patients (3 men, 12 women; age range, 19–71 years; average age 47.2 years) eligible for the study received the ZI quad approach from January 2017 through January 2020. All ZIs achieved osseointegration, with no implant loss after early healing and a mean follow‐up of 17.2 ± 6.2 months. Thirteen of 15 patients (86.7%) received immediate loading. No critical anatomic structure injuries occurred during surgery. Most mesially placed implants (23/30, 76.6%) presented ZAGA 2 and 3, and most distally placed implants were distributed in ZAGA 0 (20/30, 66.7%). Discussion In terms of realizing immediate loading in CH4 patients with a knife‐edge ridge form in the anterior maxilla, quad approaches have advantages over other grafting methods. At the same time, it seems the survival rate of zygomatic implants is comparable with that of other indications. With the limitations of this study, the quad approach might be a feasible option to realize edentulous maxillary reconstruction and to make immediate loading possible.
The aim of this study was to construct crosslinked polylysine-hyaluronic acid microspheres (pl-HAM) ladened with gingival mesenchymal stem cells (GMSCs) and explore its biologic behavior in soft tissue regeneration.
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