biomedical imaging. This tech nique provides a fast and cost-effective high resolution imaging method compared withcurrent expensive imaging modalities. To better improvespatial resolution in phase contrast optical imaging, goldnanoshells are used as contrast agents. Gold nanoshellsconstitute a novel kind of optically tunable nanoparticleconsisting of a dielectric silica core surrounded by a thingold layer. Gold nanoshells offer a variety of biomedicalapplications, such as blood immunoassay,
Although various scoring systems for measuring urticaria severity have been introduced, most rely on subjective criteria. Therefore, additional objective criteria such as laboratory markers would be helpful adjuncts in making this assessment. To evaluate the usefulness of three laboratory markers [D‐dimer, C‐reactive protein (CRP), and total IgE] in assessing disease severity of both acute urticaria (AU) and chronic urticaria (CU). We conducted a retrospective analysis of 94 patients with urticaria. Correlations between the aforementioned laboratory markers and the Urticaria Activity Score (UAS) were calculated. A substantial proportion of patients with urticaria (acute 43.5%; chronic 39.6%) had an increased D‐dimer level. Additionally, there was a significant correlation between D‐dimer level and UAS (AU r = 0.60, P < 0.001; CU r = 0.37, P < 0.05). However, there was no significant correlation between UAS and either CRP or total IgE. D‐dimer level could be used as a marker of disease severity for both AU and CU. However, CRP and total IgE are not as reliable in predicting disease severity.
Phase contrast radiography (PCR) techniques are becoming important analytical tools for imaging biological samples. The authors aimed to evaluate a possible use of PCR in examining radiological microscopic findings of cat normal spinal cord without any staining procedure in paraffin blocked specimens. The PCR experiments were implemented at the International Consortium of Phase Contrast Imaging and Radiology (ICPCIR) (7B2) beamline at the Pohang Light Source in Korea. In the phase contrast radiography, the grey and white matters of the spinal cord were demarcated with the grey matter in an 'H' shape, similar to the histological structure by light microscopy. The dorsal, intermediate and ventral grey matters were clearly visible as well as other columns and funiculi. The authors suggest that PCR could be a useful tool for microscopic morphological investigation of spinal cord without any staining procedure.
In this research, the method how to estimate the image quality for different scanning rate is suggested and experimentally shown with the laboratory-built confocal laser scanning microscope. The confocal microscope is designed for in vivo reflectance imaging of a biological tissue, which uses the refractive index mismatch at the boundaries of a tissue to generate an image without any additional staining process. The two-dimensional scanning mechanism is built up with a polygonal mirror and a galvanometric mirror that can be controlled to operate at a specific speed. To examine the effect of scanning rate on the image contrast, confocal scanning images of a biological specimen are acquired with various scanning rate while the other conditions are kept same. The contrast of confocal microscopic image is transformed into the numeric expression to describe the relation between image contrast and scanning rate quantitatively. Results suggest some useful methodology of how to determine the allowable maximum scanning rate for the specific application of confocal microscopy.
Syringoma is common benign neoplasm that is mostly seen around the eyes.However these tumors can occur in atypical locations such as the axilla.Although the axilla is possible site for syringoma, no previous case of syringoma limited to the axilla has been reported in Korea.We report here on a case of syringoma that appeared as grouped yellowbrownish papules limited to the axillae of a 24-year-old woman.(Ann Dermatol 22(1) 85∼87, 2010) -
This study used raw data obtained from the Adolescents’ Health Behavior Survey by government-affiliated agency open data. A total of 109,796 students were sampled. A comparative analysis was performed based on the year 2020 and when the COVID-19 pandemic occurred, in which we analyzed changes in adolescents’ depression and panic anxiety perception and dietary habits, physical factors, physical activity, and handwashing habits. There was no weight control in the second year compared to the first year of the COVID-19 pandemic, and obesity also increased. The continuation of the non-contact situation caused by COVID-19 led to a worsening of subjective health awareness, and the experience of generalized anxiety disorder, depression, sadness and hopelessness, and suicidal thoughts and attempts increased. The frequency of washing hands with soap before meals and after using the toilet at school or at home was reduced. As a result of this analysis, we believe that there needs to be a system of support in place to address the academic gaps and deficiencies in learning caused by COVID-19, and that psychological and emotional support needs to be strengthened at this time, as well as the issues to be supported after the end of the non-contact situation.
Bednar's tumour (BT) is a rare variant of dermatofibrosarcoma protuberans (DFSP). In addition to the typical histological findings of DFSP, melanin-containing dendritic cells are found in BT. Its occurrence at birth is very rare and there have been only two case reports of congenital BT in the English literature. A 12-year-old boy presented with a single, dome-shaped erythematous nodule, 25 x 15 mm in size, on the lower back. The lesion was present as a depressed patch at birth. Subsequently the lesion grew gradually to a dome-shaped mass. Histopathological examination found a dense infiltration of spindle cells arranged in a storiform pattern in the dermis, with pigmented cells admixed with the spindle cells. Cell mitosis and atypia were rarely seen. On immunohistochemical study, the tumour cells were positive for CD34 and melanin-containing cells were positive for S-100. A diagnosis of BT was made and the mass was removed by wide local excision. There was no evidence of recurrence at follow-up 8 months later.
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