Abstract Effective intratumoral distribution of anticancer agents with good tumor penetration is of great practical importance for oncotherapy. How to break the limitation of traditional passive drug delivery relying on blood circulatory system into solid tumors remains a challenge. Herein, a light‐directed self‐powered nanorobot based on zirconium‐based porphyrin metal‐organic framework (MOF) is reported for smart delivery of chemodrug and photosensitizer for deep tumor penetration. The MOF‐based carrier transporting the therapeutics is able to responsively generate hydrogen sulfide as propulsion gas and uniquely exhibits negative phototaxis in acidic tumor microenvironment. Under red light irradiation, the nanorobots are accordingly propelled from the tumor surface toward deep tumor far away from the exterior light source in a specific deep‐into‐tumor direction, greatly enhancing tumor penetration. Along with tumor‐responsive release and activation of the delivered therapeutics inside tumor tissues, photo‐chemotherapy with significantly improved efficacy is achieved.
In this paper, we have considered a new method for modeling and equalizing of nonlinear wireless channel.The Volterra structure equalizer has high computation burden and slow convergence rate due to its large number of coefficients and the pre-distortion method is very difficult to realize in actual wireless communication systems.Here, we have taken another scheme instead of those mentioned above.First, it is assumed that the nonlinear channel under consideration has a Wiener model representation.After fully estimating the parameters of the channel, which consist of a linear filter with memory and a nonlinear filter without memory, we took Hammerstein model equalizer to equalize the channel.The simulation results show the feasibility of the program by applying it to 8PSK wireless communication channel.
Ni-based coatings are prepared on 2Cr13 steel substrate by extreme high-speed laser cladding and subsequent laser remelting (EHLA-LR). The effects of laser remelting (LR) treatment on the morphology, microstructure, residual stress and corrosion resistance of extreme high-speed laser cladded (EHLA) coatings are investigated in details. The results demonstrate that the integrated EHLA-LR process could dramatically reduce the surface roughness by 86%, improve the surface compactness and optimize the surface flatness. The dendrite spacing in the near surface region of the coating via EHLA-LR decreases with refined grains, while the phases of the coatings change little in spite of LR treatment. It was found that the residual compressive stress of the coatings is maintained, but it is slightly reduced upon LR. Furthermore the coatings via EHLA-LR possess better corrosion resistance than that of coatings via EHLA owing to the increased surface compactness and grain refinement by LR process.
Real estate industry is a special field.With the development of the real estate industry,it is necessary to have numbers of higher qualified real estate agent.The real estate agent not only comply with golden rules,but also grasp basic skills to handle complex real estate transactions.
The paper introduces the concept of reverse engineering,and puts emphasis on the key technologies of data acquirement,data pretreatment,3D surface reconstruction and so on.Some applied examples in the car realm are given.Finally,the development trend of the reverse engineering technique is pointed out.
Elevating the operating temperature can effectively improve the electrode reaction and reduce the mass transfer resistance of a fuel cell caused by a double-phase fluid. Here, a copolymer containing imidazole groups and phosphonic acid groups is designed and prepared, and then, a novel proton exchange membrane (PEM) that possesses an interpenetrating polymer network structure and consists of the copolymer and perfluorosulfonic acid (PFSA) is obtained. Owing to the formed acid–base cross-linking structure, the membrane has a more compact structure, and its dimensional stability and gas permeability are significantly improved. The phosphonic acid and imidazole groups with excellent water retention ability improve the continuity of the hydrophilic region of the PEM, and the continuous acid–base pairs weaken the water dependence of proton conductivity; therefore, the prepared PEM exhibits excellent proton conductivity under high temperature conditions. Under high operating temperatures, a single cell based on the prepared PEM exhibits low impedance and excellent polarization performance; hence, it can operate stably above 100 °C. This paper provides a method to prepare an acid–base composite membrane that is promising for application at low humidity and across a range of temperature zones.
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